Longitudinal associations of fast foods, red and processed meat, alcohol and sugar-sweetened drinks with quality of life and symptoms in colorectal cancer survivors up to 24 months post-treatment
Kenkhuis MF, Mols F, van Roekel EH, Breedveld-Peters JJL, Breukink S, Janssen-Heijnen M, Keulen E, van Duijnhoven FJ, Weijenberg MP, Bours M
The British journal of nutrition · 14 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Health Foundation Limburg
- University or hospital
- University of Cambridge
- University or hospital
- Universiteit Maastricht
- Nonprofit
- KWF Kankerbestrijding
- Nonprofit
- Wereld Kanker Onderzoek Fonds
- Nonprofit
- World Cancer Research Fund
- Grants
- KWF Kankerbestrijding (UM 2014–6877); KWF Kankerbestrijding (UM-2012-5653); KWF Kankerbestrijding (UM 2010-4867 and UM 2012-5653); Health Foundation Limburg (00005739); Wereld Kanker Onderzoek Fonds (2016/1620); World Cancer Research Fund (00005739); Wereld Kanker Onderzoek Fonds (2017/1619); World Cancer Research Fund (2017/1619); World Cancer Research Fund (2016/1620); Wereld Kanker Onderzoek Fonds (00005739); KWF Kankerbestrijding (UM‐2010‐4867); KWF Kankerbestrijding (2012-5653)
Based on 6 listed funder(s).
Publication
- Published
- 2022-09-27 · Br J Nutr · vol. 130 · issue 1 · pp. 114–126
- Publisher
- Cambridge University Press
- Cited
- 22 citations · more than 93% of similar papers · 3.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 44 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Cancer Treatment and Pharmacology · Ginseng Biological Effects and Applications · Ginkgo biloba and Cashew Applications
- Keywords
- Medicine, Longitudinal study, Quality of life (healthcare), Colorectal cancer, Confounding, Cohort study, Red meat, Environmental health, Internal medicine, Cancer
- MeSH
- humans, colorectal neoplasms, fatigue, ethanol, carbohydrates, prospective studies, quality of life, meat, fast foods, cancer survivors, sugars, sugar-sweetened beverages
10 authors
From NL
- Marlou‐Floor Kenkhuis · correspondingMaastricht University
- Floortje MolsTilburg University
- Eline H. van RoekelMaastricht University
- José J.L. Breedveld-PetersMaastricht University
- Stéphanie O. BreukinkMaastricht University Medical Centre
- Maryska L.G. Janssen‐HeijnenMaastricht University; VieCuri Medisch Centrum
Abstract
Unhealthy dietary habits can contribute to the development of colorectal cancer (CRC). Such habits may also be associated with post-treatment symptoms experienced by CRC survivors. Therefore, we aimed to assess longitudinal associations of post-treatment unhealthy dietary habits, i.e. intake of ultra-processed foods (UPF), red and processed meat, alcohol and sugar-sweetened drinks, with health-related quality of life (HRQoL), fatigue and chemotherapy-induced peripheral neuropathy (CIPN) in CRC survivors from 6 weeks up to 24 months post-treatment. In a prospective cohort among stage I-III CRC survivors (n 396), five repeated home visits from diagnosis up to 24 months post-treatment were executed. Dietary intake was measured by 7-d dietary records to quantify consumption of UPF, red and processed meat, alcohol and sugar-sweetened drinks. HRQoL, fatigue and CIPN were measured by validated questionnaires. We applied confounder-adjusted linear mixed models to analyse longitudinal associations from 6 weeks until 24 months post-treatment. We applied a post hoc time-lag analysis for alcohol to explore the directionality. Results showed that higher post-treatment intake of UPF and sugar-sweetened drinks was longitudinally associated with worsened HRQoL and more fatigue, while higher intake of UPF and processed meat was associated with increased CIPN symptoms. In contrast, post-treatment increases in alcohol intake were longitudinally associated with better HRQoL and less fatigue; however, time-lag analysis attenuated these associations. In conclusion, unhealthy dietary habits are longitudinally associated with lower HRQoL and more symptoms, except for alcohol. Results from time-lag analysis suggest no biological effect of alcohol; hence, the longitudinal association for alcohol should be interpreted with caution.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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