Metabolic Efficacy of Time-Restricted Eating in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Liu L, Chen W, Wu D, Hu F
The Journal of clinical endocrinology and metabolism · 65 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National Key Research and Development Program of China
- Government
- National Nature Science Foundation of China
- Government
- National Key R&D Program of China
- Grants
- National Natural Science Foundation of China (31871180); National Key Research and Development Program of China (2020YFA0803604); National Natural Science Foundation of China (91957113)
Based on 4 listed funder(s).
Publication
- Published
- 2022-10-03 · J Clin Endocrinol Metab · vol. 107 · issue 12 · pp. 3428–3441
- Publisher
- Oxford University Press
- Cited
- 81 citations · more than 92% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 65 works
- Access
- Paywalled
- Research areas
- Dietary Effects on Health · Enhanced Recovery After Surgery · Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Meta-analysis, Randomized controlled trial, Medicine, Psychology, Gerontology, Internal medicine
- MeSH
- humans, obesity, body weight, adult, overweight, cholesterol, ldl, randomized controlled trials as topic
4 authors
From CN
- Lili LiuCentral South University; Second Xiangya Hospital of Central South University
- Wei ChenCentral South University; Second Xiangya Hospital of Central South University
- Dan WuCentral South University; Second Xiangya Hospital of Central South University
- Fang Hu · correspondingCentral South University; Second Xiangya Hospital of Central South University
Abstract
Context
Time-restricted eating (TRE), which restricts food intake to a limited duration of the day, is a key regimen of intermittent fasting.
Objective
The aim of our study was to provide an up-to-date meta-analysis and systematic review to evaluate the efficacy of TRE on weight loss and other metabolic-related parameters in adults.
Methods
We searched PubMed, EMBASE, and the Cochrane Library for relevant studies published before February 26, 2022. Study duration of TRE was at least 4 weeks. Body weight and other metabolic-related continuous parameters were described as weighted mean difference (WMD) with 95% CI.
Results
Seventeen randomized controlled trials involving 899 participants were analyzed. The pooled meta-analysis has shown that TRE contributed to a significant decrease in body weight with a WMD of -1.60 kg (95% CI -2.27 to -0.93) and fat mass with WMD -1.48 kg (95% CI -1.59 to -1.38). Subgroup analysis showed that TRE could reduce body weight and fat mass especially in overweight participants with WMD -1.43 kg (95% CI -2.05 to -0.81) and -1.56 kg (95% CI -1.67 to -1.44), respectively. TRE also showed beneficial effects on the lipid spectrum in overweight participants, including decreased levels of triglyceride (WMD -12.71 mg/dL, 95% CI -24.9 to -0.52), total cholesterol (WMD -6.45 mg/dL, 95% CI -7.40 to -5.49), and low-density lipoprotein cholesterol (WMD -7.0 mg/dL, 95% CI -9.74 to -4.25). However, compared with control, TRE had no significant effects on waist circumference, body mass index, glycosylated hemoglobin, or blood pressure.
Conclusion
This updated meta-analysis found that TRE may be an effective approach to improve the metabolic state of nonobese subjects, especially in overweight participants.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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