Funded in part by Amgen, Novo Nordisk
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial
Manoogian ENC, Zadourian A, Lo HC, Gutierrez NR, Shoghi A, Rosander A, Pazargadi A, Ormiston CK, Wang X, Sui J, Hou Z, Fleischer JG, Golshan S, Taub PR, Panda S
Cell metabolism · 156 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Nonprofit
- Robert Wood Johnson Foundation
- Nonprofit
- Larry L. Hillblom Foundation
- Company
- Amgen
- Nonprofit
- William H. Donner Foundation
- Company
- Novo Nordisk
- Government
- Federal Emergency Management Agency
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NCI NIH HHS
- Government
- NCI
- Nonprofit
- Larry L Hillblom Foundation
- Government
- NIDDK
- Government
- NIDDK NIH HHS
- Grants
- Federal Emergency Management Agency (EMW-2016-FP-00788); National Cancer Institute (CA258221); National Cancer Institute (CA236352); Federal Emergency Management Agency (FEMA-EMW-2016-FP-00788); National Institute of Diabetes and Digestive and Kidney Diseases (DK118278); National Cancer Institute (R01 CA236352); National Cancer Institute (P30 CA-014195); National Cancer Institute (R01 CA258221); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK118278)
Based on 13 listed funder(s).
Publication
- Published
- 2022-10-01 · Cell Metab · vol. 34 · issue 10 · pp. 1442–1456.e7
- Publisher
- Cell Press
- Cited
- 185 citations · more than 100% of similar papers · 28.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 64 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Sleep and Work-Related Fatigue · Dietary Effects on Health · Sleep and related disorders
- Keywords
- Medicine, Randomized controlled trial, Glycated hemoglobin, Blood pressure, Adverse effect, Physical therapy, Shift work, Internal medicine, Gerontology, Diabetes mellitus, Endocrinology, Type 2 diabetes, Psychiatry
- MeSH
- humans, cardiovascular diseases, fasting, feasibility studies, blood pressure, quality of life, adult, middle aged, female, male, young adult, glycated hemoglobin
15 authors
From US
- Emily N. C. ManoogianSalk Institute for Biological Studies
- Adena ZadourianUniversity of California San Diego
- Hannah C. LoUniversity of California San Diego
- Nikko R. GutierrezSalk Institute for Biological Studies
- Azarin ShoghiSalk Institute for Biological Studies
- Ashley RosanderUniversity of California San Diego
Abstract
Over a quarter of the workforce in industrialized countries does shift work, which increases the risk for cardiometabolic disease. Yet shift workers are often excluded from lifestyle intervention studies to reduce this risk. In a randomized control trial with 137 firefighters who work 24-h shifts (23-59 years old, 9% female), 12 weeks of 10-h time-restricted eating (TRE) was feasible, with TRE participants decreasing their eating window (baseline, mean 14.13 h, 95% CI 13.78-14.47 h; intervention, 11.13 h, 95% CI 10.73-11.54 h, p = 3.29E-17) with no adverse effects, and improved quality of life assessed via SF-36 (ClinicalTrials.gov: NCT03533023). Compared to the standard of care (SOC) arm, TRE significantly decreased VLDL particle size. In participants with elevated cardiometabolic risks at baseline, there were significant reductions in TRE compared to SOC in glycated hemoglobin A1C and diastolic blood pressure. For individuals working a 24-h shift schedule, TRE is feasible and can improve cardiometabolic health, especially for individuals with increased risk. VIDEO ABSTRACT.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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