Funded in part by Novo Nordisk Fonden
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial
Haganes KL, Silva CP, Eyjólfsdóttir SK, Steen S, Grindberg M, Lydersen S, Hawley JA, Moholdt T
Cell metabolism · 96 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- University or hospital
- Norges Teknisk-Naturvitenskapelige Universitet
- Nonprofit
- European Foundation for the Study of Diabetes
- Government
- Helse Midt-Norge
- Company
- Novo Nordisk Fonden
- University or hospital
- Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet
- Grants
- Novo Nordisk Fonden (NNF19SA0058975); Novo Nordisk Fonden (NNF19SA058975); Norges Teknisk-Naturvitenskapelige Universitet (NNF14OC0011493); Helse Midt-Norge (2020/39645)
Based on 5 listed funder(s).
Publication
- Published
- 2022-10-01 · Cell Metab · vol. 34 · issue 10 · pp. 1457–1471.e4
- Publisher
- Cell Press
- Cited
- 137 citations · more than 99% of similar papers · 12.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Keywords
- Medicine, Overweight, Glycemic, High-intensity interval training, Interval training, Randomized controlled trial, Obesity, Internal medicine, Glycemic load, Confidence interval, Physical therapy, Body mass index, Weight loss, Glycemic index, Insulin
- MeSH
- humans, cardiovascular diseases, obesity, glucose, exercise, body composition, female, overweight, glycated hemoglobin
8 authors
From NO, AU
- Kamilla L. Haganes · correspondingNorwegian University of Science and Technology; St Olav's University Hospital
- Catalina P. SilvaNorwegian University of Science and Technology
- Svala K. EyjólfsdóttirNorwegian University of Science and Technology
- Sandra SteenNorwegian University of Science and Technology
- Martine GrindbergNorwegian University of Science and Technology
- Stian LydersenNorwegian University of Science and Technology
Abstract
Diet modification and exercise training are primary lifestyle strategies for obesity management, but poor adherence rates limit their effectiveness. Time-restricted eating (TRE) and high-intensity interval training (HIIT) improve cardiometabolic health in at-risk individuals, but whether these two interventions combined induce superior improvements in glycemic control than each individual intervention is not known. In this four-armed randomized controlled trial (ClinicalTrials.gov NCT04019860), we determined the isolated and combined effects of 7 weeks of TRE (≤10-h daily eating window, with ad libitum energy intake) and HIIT (three exercise sessions per week), compared with a non-intervention control group, on glycemic control and secondary cardiometabolic outcomes in 131 women (36.2 ± 6.2 years) with overweight/obesity. There were no statistically significant effects after isolated TRE, HIIT, or a combination (TREHIIT) on glucose area under the curve during an oral glucose tolerance test (the primary outcome) compared with the control group (TRE, -26.3 mmol/L; 95% confidence interval [CI], -82.3 to 29.7, p = 0.36; HIIT, -53.8 mmol/L; 95% CI, -109.2 to 1.6, p = 0.057; TREHIIT, -41.3 mmol/L; 95% CI, -96.4 to 13.8, p = 0.14). However, TREHIIT improved HbA1c and induced superior reductions in total and visceral fat mass compared with TRE and HIIT alone. High participant adherence rates suggest that TRE, HIIT, and a combination thereof may be realistic diet-exercise strategies for improving markers of metabolic health in women at risk of cardiometabolic disease.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.