Effect of time-restricted eating on sex hormone levels in premenopausal and postmenopausal females
Kalam F, Akasheh RT, Cienfuegos S, Ankireddy A, Gabel K, Ezpeleta M, Lin S, Tamatam CM, Reddy SP, Spring B, Khan SA, Varady KA
Obesity (Silver Spring, Md.) · 18 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NCI NIH HHS
- Government
- NIDDK NIH HHS
- Grants
- National Cancer Institute (#T32CA193193); National Cancer Institute (R01CA257807); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119783); National Institutes of Health (R01 DK119783)
Based on 5 listed funder(s).
Publication
- Published
- 2022-10-06 · Obesity (Silver Spring) · vol. 31 · issue S1 · pp. 57–62
- Publisher
- Wiley
- Cited
- 18 citations · more than 86% of similar papers · 1.8× the field average
- References
- 29 works
- Access
- Free to read
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Eating Disorders and Behaviors
- Keywords
- Androstenedione, Sex hormone-binding globulin, Internal medicine, Endocrinology, Estrone, Dehydroepiandrosterone, Medicine, Testosterone (patch), Hormone, Menopause, Estrogen, Postmenopausal women, Androgen
- MeSH
- humans, dehydroepiandrosterone, testosterone, estradiol, progesterone, gonadal steroid hormones, sex hormone-binding globulin, androgens, postmenopause, adult, female, intermittent fasting
12 authors
From US, JO
- Faiza KalamNorthwestern University
- Rand T. AkashehAmerican University of Madaba; University of Illinois Chicago
- Sofia CienfuegosUniversity of Illinois Chicago
- Aparna AnkireddyUniversity of Illinois Chicago
- Kelsey GabelUniversity of Illinois Chicago
- Mark EzpeletaUniversity of Illinois Chicago
Abstract
Objective
Concerns have been raised regarding the impact of time-restricted eating (TRE) on sex hormones in females. This study examined how TRE affects sex steroids in premenopausal and postmenopausal females.
Methods
This is a secondary analysis of an 8-week TRE study (4- to 6-hour eating window) conducted in adults with obesity. Men and perimenopausal females were excluded. Females were classified into two groups based on menstrual status: premenopausal (n = 12) or postmenopausal (n = 11).
Results
After 8 weeks, body weight decreased in premenopausal females (-3% ± 2%) and postmenopausal females (-4% ± 2%) (main effect of time, p < 0.001), with no difference between groups (no group × time interaction). Circulating levels of testosterone, androstenedione, and sex hormone binding globulin (SHBG) did not change in either group (no group × time interaction). Dehydroepiandrosterone (DHEA) concentrations decreased (p < 0.05) in premenopausal (-14% ± 32%) and postmenopausal females (-13% ± 34%; main effect of time, p = 0.03), with no difference between groups. Estradiol, estrone, and progesterone were measured only in postmenopausal females, and they remained unchanged.
Conclusions
In premenopausal females, androgens and SHBG remained unchanged during TRE, whereas DHEA decreased. In postmenopausal females, estrogens, progesterone, androgens, and SHBG did not change, but DHEA was reduced.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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