Association of Ultraprocessed Food Consumption With Risk of Dementia: A Prospective Cohort Study
Li H, Li S, Yang H, Zhang Y, Zhang S, Ma Y, Hou Y, Zhang X, Niu K, Borné Y, Wang Y
Neurology · 90 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Medical Research Council
- Grants
- Medical Research Council (MC_PC_17228)
Based on 1 listed funder(s).
Publication
- Published
- 2022-07-28 · Neurology · vol. 99 · issue 10 · pp. e1056–e1066
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 107 citations · more than 100% of similar papers · 16.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Paywalled
- Research areas
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Nutritional Studies and Diet
- Keywords
- Dementia, Hazard ratio, Medicine, Vascular dementia, Confidence interval, Proportional hazards model, Disease, Incidence (geometry), Relative risk, Alzheimer's disease, Internal medicine, Gerontology
- MeSH
- humans, dementia, vascular, diet, prospective studies, food handling, fast foods
11 authors
From CN
- Huiping LiTianjin University of Traditional Chinese Medicine; Tianjin Medical University
- Shu LiTianjin University of Traditional Chinese Medicine; Tianjin Medical University
- Hongxi YangTianjin University of Traditional Chinese Medicine; Tianjin Medical University
- Yuan ZhangTianjin University of Traditional Chinese Medicine; Tianjin Medical University
- Shunming ZhangTianjin University of Traditional Chinese Medicine; Tianjin Medical University
- Yue MaTianjin University of Traditional Chinese Medicine; Tianjin Medical University
Abstract
Background and objectives
There has been a growing body of evidence associating consumption of ultraprocessed foods (UPF) with adverse health outcomes including depression, cardiovascular disease, and all-cause mortality. However, whether UPF are associated with dementia is unknown. The authors investigated the associations between UPF and dementia incidence in the UK Biobank.
Methods
We included 72,083 participants (55 years or older) who were free from dementia at baseline and provided at least 2 times 24-hour dietary assessments from the UK Biobank study. Follow-up occurred through March 2021. UPF were defined according to the NOVA classification. Incident all-cause dementia comprising Alzheimer disease (AD) and vascular dementia was ascertained through electronic linkages to hospital and mortality records. Cox proportional hazards were used to estimate the association between the proportion (%) of UPF in the diet and the subsequent risk of dementia. In addition, substitution analysis was used to estimate the risk of dementia when substituting UPF with an equivalent proportion of unprocessed or minimally processed foods.
Results
During a total of 717,333 person-years of follow-up (median 10.0 years), 518 participants developed dementia, of whom 287 developed AD and 119 developed vascular dementia. In the fully adjusted model, consumption of UPF was associated with higher risk of dementia (hazard ratio [HR] for 10% increase in UPF 1.25; 95% CI 1.14-1.37), AD (HR 1.14; 95% CI 1.00-1.30), and vascular dementia (HR 1.28; 95% CI 1.06-1.55), respectively. In addition, replacing 10% of UPF weight in diet with an equivalent proportion of unprocessed or minimally processed foods was estimated to be associated with a 19% lower risk of dementia (HR 0.81; 95% CI 0.74-0.89).
Discussion
In this prospective cohort study, higher consumption of UPF was associated with higher risk of dementia, whereas substituting unprocessed or minimally processed foods for UPF was associated with lower risk of dementia.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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