Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial
He M, Wang J, Liang Q, Li M, Guo H, Wang Y, Deji C, Sui J, Wang YW, Liu Y, Zheng Y, Qian B, Chen H, Ma M, Su S, Geng H, Zhou WX, Guo X, Zhu WZ, Zhang M, Chen Z, Rensen PCN, Hui CC, Wang Y, Shi B
Cell reports. Medicine · 71 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Xi’an Jiaotong University
- Government
- National Key Research and Development Program of China
- Grants
- National Key Research and Development Program of China (2018YFC1311501)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-10-01 · Cell Rep Med · vol. 3 · issue 10 · p. 100777
- Publisher
- Elsevier BV
- Cited
- 108 citations · more than 99% of similar papers · 9.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 74 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Diet, Metabolism, and Disease
- Keywords
- Medicine, Dyslipidemia, Metabolic syndrome, Weight loss, Randomized controlled trial, Glycemic, Internal medicine, Endocrinology, Gastroenterology, Diabetes mellitus, Obesity
- MeSH
- humans, body weight, uric acid, blood glucose, intra-abdominal fat, dyslipidemias, diet, carbohydrate-restricted, metabolic syndrome
28 authors
From CN, NL, CA
- Mingqian HeFirst Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Jingya WangFirst Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Qian LiangFirst Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Meng LiFirst Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Hui GuoFirst Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
- Yue WangFirst Affiliated Hospital of Xi'an Jiaotong University; Xi'an Jiaotong University
Abstract
Overconsumption of carbohydrate-rich food combined with adverse eating patterns contributes to the increasing incidence of metabolic syndrome (MetS) in China. Therefore, we conducted a randomized trial to determine the effects of a low-carbohydrate diet (LCD), an 8-h time-restricted eating (TRE) schedule, and their combination on body weight and abdominal fat area (i.e., primary outcomes) and cardiometabolic outcomes in participants with MetS. Compared with baseline, all 3-month treatments significantly reduce body weight and subcutaneous fat area, but only TRE and combination treatment reduce visceral fat area (VFA), fasting blood glucose, uric acid (UA), and dyslipidemia. Furthermore, compared with changes of LCD, TRE and combination treatment further decrease body weight and VFA, while only combination treatment yields more benefits on glycemic control, UA, and dyslipidemia. In conclusion, without change of physical activity, an 8-h TRE with or without LCD can serve as an effective treatment for MetS (ClinicalTrials.gov: NCT04475822).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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