Metabolic profiles of ultra-processed food consumption and their role in obesity risk in British children
Handakas E, Chang K, Khandpur N, Vamos EP, Millett C, Sassi F, Vineis P, Robinson O
Clinical nutrition (Edinburgh, Scotland) · 45 citations
Review labels
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How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Wellcome Trust
- Government
- UK Research and Innovation
- Government
- National Institute for Health and Care Research
- Nonprofit
- British Heart Foundation
- Government
- Department of Health and Social Care
- Government
- European Commission
- University or hospital
- University of Bristol
- Government
- National Institutes of Health
- Government
- Medical Research Council
- University or hospital
- School for Public Health Research
- Grants
- School for Public Health Research (Grant Reference Number PD-SPH2015); University of Bristol (MC_UU_12013/1); European Commission (774548); Medical Research Council (217065/Z/19/Z); University of Bristol (217065/Z/19/Z); Wellcome Trust (076467); University of Bristol (076467); Medical Research Council (076467); Medical Research Council (MC_UU_12013); National Institute for Health and Care Research (MC_UU_12013/1); National Institute for Health and Care Research (217065/Z/19/Z); Wellcome Trust (217065/Z/19/Z); Medical Research Council (076467/Z/05/Z); Medical Research Council (217065); University of Bristol (092731); British Heart Foundation (PD-SPH-2015); European Commission (HORIZON2020); Medical Research Council (PD-SPH-2015); National Institutes of Health (092731); Medical Research Council (MCUU12013/1); Wellcome Trust (092731); National Institutes of Health (217065/Z/19/Z); School for Public Health Research (PD‐SPH‐2015); Department of Health and Social Care (PD-SPH-2015); National Institute for Health and Care Research (PD‐SPH‐2015); Medical Research Council (092731); Medical Research Council (5R01HL071248-07); Medical Research Council (MR/M501669/1); Wellcome Trust (217065); Wellcome Trust (PD-SPH-2015); Wellcome Trust (076467/Z05/z); Wellcome Trust (086676/Z/08/Z); National Institutes of Health (R01 DK077659); National Institutes of Health (DK077659)
Based on 10 listed funder(s).
Publication
- Published
- 2022-09-15 · Clin Nutr · vol. 41 · issue 11 · pp. 2537–2548
- Publisher
- Elsevier BV
- Cited
- 57 citations · more than 98% of similar papers · 8.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 77 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Nutritional Studies and Diet
- Keywords
- Medicine, Obesity, Glutamine, Metabolic syndrome, Prospective cohort study, Metabolome, Internal medicine, Cohort, Endocrinology, Physiology, Food science, Amino acid, Metabolite, Biology, Biochemistry
- MeSH
- humans, citrates, fatty acids, monounsaturated, glutamine, amino acids, aromatic, diet, cross-sectional studies, food handling, child, metabolome, pediatric obesity
8 authors
From GB, US, BR, GR
- Evangelos HandakasNatural Environment Research Council; Imperial College London; Medical Research Council
- Kiara ChangImperial College London
- Neha KhandpurHarvard University; Universidade de São Paulo
- Eszter Panna VamosImperial College London
- Christopher J. MillettPublic Health England; National School of Public Health; Imperial College London
- Franco SassiImperial College London
Abstract
Background & aims
Higher consumption of ultra-processed foods (UPF) has been associated with childhood obesity, but underlying mechanisms remain unclear. We investigated plasma nuclear magnetic resonance metabolic profiles of higher UPF consumption and their role in obesity risk in the British ALSPAC cohort.
Methods
We performed cross-sectional and prospective metabolome wide association analyses of UPF, calculated from food diaries using the NOVA classification. In cross-sectional analysis, we tested the association between UPF consumption and metabolic profile at 7 years (N = 4528), and in the prospective analysis we tested the association between UPF consumption at 13 years and metabolic profile at 17 years (N = 3086). Effects of UPF-associated metabolites at 7 years on subsequent fat mass accumulation were assessed using growth curve models.
Results
At 7 years, UPF was associated with 115 metabolic traits including lower levels of branched-chain and aromatic amino acids and higher levels of citrate, glutamine, and monounsaturated fatty acids, which were also associated with greater fat mass accumulation. Reported intake of nutrients mediated associations with most metabolites, except for citrate.
Conclusions
UPF consumption among British children is associated with perturbation of multiple metabolic traits, many of which contribute to child obesity risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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