Effect of magnesium supplementation on pregnancy outcome in gestational diabetes mellitus patients: A meta-analysis of randomized controlled trials
Qu Q, Rong R, Yu J
Food science & nutrition · 11 citations
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Nantong University
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-09-07 · Food Sci Nutr · vol. 10 · issue 10 · pp. 3193–3202
- Publisher
- Wiley
- Cited
- 15 citations · more than 79% of similar papers · 1.4× the field average
- References
- 59 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Pregnancy-related medical research
- Keywords
- Medicine, Glycemic, Randomized controlled trial, Gestational diabetes, Internal medicine, Diabetes mellitus, Meta-analysis, Pregnancy, Insulin, Oxidative stress, Endocrinology, Obstetrics, Gestation
3 authors
From CN
- Qiuchan QuNantong University; Nantong Maternity and Child Health Hospital
- Rong RongNantong University; Nantong Maternity and Child Health Hospital
- Jinhua Yu · correspondingNantong University; Nantong Maternity and Child Health Hospital
Abstract
Conflicting evidence exists regarding the effectiveness of magnesium supplementation during pregnancy in gestational diabetes mellitus (GDM) patients. This meta-analysis examines the effect of magnesium on glycemic indices and metabolic status in GDM. We searched databases for randomized controlled trials (RCTs) conducted, and after applying inclusion and exclusion criteria, a total of four RCTs were considered eligible for the analysis. Outcome parameters included markers for glycemic control and metabolic status. A total of four RCTs with 198 participants (control = 99; magnesium supplemented = 99) were selected for the analysis. Magnesium supplementation resulted in a significant reduction in markers of glycemic control-fasting plasma glucose (standard mean difference ( μ ^ ) = -0.83; 95% CI: [-1.13, -0.54]; p-value p-value p-value = .03) of the pregnant women. No significant effect on GSH and CRP levels was observed. This study provides evidence of the positive effects of magnesium intervention on insulin sensitivity and oxidative stress in GDM patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.