Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome
Atzeni A, Martínez MÁ, Babio N, Konstanti P, Tinahones FJ, Vioque J, Corella D, Fitó M, Vidal J, Moreno-Indias I, Pertusa-Martinez S, Álvarez-Sala A, Castañer O, Goday A, Damas-Fuentes M, Belzer C, Martínez-Gonzalez MÁ, Hu FB, Salas-Salvadó J
Frontiers in nutrition · 56 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Possibly industry funded
- Government
- European Commission
- Government
- Generalitat Valenciana
- University or hospital
- Institució Catalana de Recerca i Estudis Avançats
- University or hospital
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Government
- National Institutes of Health
- Government
- Horizon 2020 Framework Programme
- Government
- Instituto de Salud Carlos III
- Government
- European Regional Development Fund
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Grants
- National Institutes of Health (PROMETEO 17/2017); Instituto de Salud Carlos III (PI16/); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK127601); Generalitat Valenciana (PI13/00462); Instituto de Salud Carlos III (PI13/00462); Institució Catalana de Recerca i Estudis Avançats (PI13/00462); Generalitat Valenciana (17/2017); Generalitat Valenciana (PI16/00501); Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (PI16/00501); Instituto de Salud Carlos III (H2020-SFS-2016-2); Generalitat Valenciana (PROMETEO 17/2017); European Regional Development Fund (H2020); National Institutes of Health (PI19/00576); Instituto de Salud Carlos III (PI19/00576); Instituto de Salud Carlos III (PI16/00501); National Institutes of Health (PI16/00501); Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (PI13/00462); Horizon 2020 Framework Programme (Eat2beNICE); National Institutes of Health (PI13/00462); European Regional Development Fund (PI19/00576); Institució Catalana de Recerca i Estudis Avançats (PI16/00501); Instituto de Salud Carlos III (PROMETEO 17/2017); Generalitat Valenciana (PROMETEO/21/2021); European Regional Development Fund (PI16/00501); Generalitat Valenciana (PI19/00576); National Institutes of Health (EU-H2020); European Regional Development Fund (PI13/00462); Instituto de Salud Carlos III (H2020); National Institutes of Health (H2020); Institució Catalana de Recerca i Estudis Avançats (PI19/00576)
Based on 10 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-10-10 · Front Nutr · vol. 9 · p. 976547
- Publisher
- Frontiers Media
- Cited
- 78 citations · more than 99% of similar papers · 12.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Obesity, Physical Activity, Diet
- Keywords
- Overweight, Obesity, Gut flora, Medicine, Population, Metabolic syndrome, Anthropometry, Feces, Body mass index, Food group, Environmental health, Physiology, Internal medicine, Biology, Immunology
19 authors
From ES, NL, US
- Alessandro Atzeni · correspondingInstituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Universitat Rovira i Virgili
- María Ágeles MartínezInstituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Universitat Rovira i Virgili
- Nancy BabióInstituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Universitat Rovira i Virgili
- Prokopis KonstantiWageningen University & Research
- Francisco José TinahonesInstituto de Salud Carlos III; Centro de Investigación Biomédica en Red; Instituto de Investigación Biomédica de Málaga
- Jesús VioquéUniversitat de Miguel Hernández d'Elx; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Instituto de investigación sanitaria y biomédica de Alicante
Abstract
The production and consumption of ultra-processed foods (UPF) has increased considerably during the last years worldwide. Collective evidence shows the association between UPF consumption and adverse health outcomes, including inflammatory gastro-intestinal disorders and obesity. The gut microbiota has been suggested as potential mediator of the effects of UPF consumption on metabolism and health. However, few studies have been conducted in order to elucidate these aspects. Therefore, the aim of the present study was to assess the cross-sectional associations between UPF consumption and gut microbiota in a population of senior subjects (n = 645) within the frame of the PREDIMED-Plus trial. Eligible participants were men and women (aged 55-75 years), without documented history of cardiovascular disease at enrollment, with overweight/obesity (body mass index ≤ 27 and 2) and metabolic syndrome. Using the information of food frequency questionnaires, the consumption of UPF, expressed as a percentage of total dietary energy intake in kcal/day, was calculated considering those food items classified in group 4 of NOVA system. Population was categorized according to tertiles of UPF consumption. Taxonomic fecal microbiota information, along with blood biochemical parameters, anthropometric measurements and clinical data were obtained. Bioinformatics analysis was performed to study the association between fecal microbiota composition and UPF consumption. We observed that subjects allocated in the highest tertile of UPF consumption (21.4 ± 5.0 % kcal/day) presented lower adherence to MedDiet (p p p Alloprevotella (p = 0.041 vs. T2; p = 0.065 vs. T3), Negativibacillus (p = 0.096 vs. T3), Prevotella (p = 0.116 vs. T3), and Sutterella (p = 0.116 vs. T2). UPF consumption was positively associated with lower adherence to MedDiet and higher total energy intake in senior subjects with overweight obesity and metabolic syndrome. In addition, positive association with specific fecal microbiota taxa related to inflammatory gastro-intestinal diseases and low consumption of fruits and vegetables, was observed.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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