Intake of Ultra-processed Foods Is Associated with an Increased Risk of Crohn's Disease: A Cross-sectional and Prospective Analysis of 187 154 Participants in the UK Biobank
Chen J, Wellens J, Kalla R, Fu T, Deng M, Zhang H, Yuan S, Wang X, Theodoratou E, Li X, Satsangi J
Journal of Crohn's & colitis · 90 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Key Project of Research and Development Plan of Hunan Province
- Nonprofit
- Cancer Research UK
- Government
- National Natural Science Foundation of China
- Government
- Medical Research Council
- Government
- Science Fund for Distinguished Young Scholars of Zhejiang Province
- Government
- Natural Science Fund for Distinguished Young Scholars of Zhejiang Province
- Grants
- Key Project of Research and Development Plan of Hunan Province (2019SK 2041); Cancer Research UK (C31250/A22804); National Natural Science Foundation of China (81970494); Cancer Research UK (66354); Medical Research Council (MC_PC_17228); Science Fund for Distinguished Young Scholars of Zhejiang Province (C31250/A22804); Key Project of Research and Development Plan of Hunan Province (81970494); Science Fund for Distinguished Young Scholars of Zhejiang Province (LR22H260001); National Natural Science Foundation of China (2019SK2041); Cancer Research UK (22804)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-10-25 · J Crohns Colitis · vol. 17 · issue 4 · pp. 535–552
- Publisher
- Oxford University Press
- Cited
- 115 citations · more than 100% of similar papers · 18.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (hybrid journal) · OTHER-OA
- Research areas
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Health, Technology, Consumer Behavior
- Keywords
- Medicine, Hazard ratio, Incidence (geometry), Internal medicine, Ulcerative colitis, Prospective cohort study, Odds ratio, Confidence interval, Inflammatory bowel disease, Crohn's disease, Cross-sectional study, Logistic regression, Proportional hazards model, Cohort, Disease, Pathology
- MeSH
- humans, colitis, ulcerative, inflammatory bowel diseases, crohn disease, risk factors, prospective studies, cross-sectional studies, middle aged, biological specimen banks, united kingdom, food, processed
11 authors
From CN, GB, BE, SE
- Jie ChenCentral South University; Third Xiangya Hospital; Second Affiliated Hospital of Zhejiang University
- Judith WellensJohn Radcliffe Hospital; KU Leuven
- Rahul KallaCentre for Inflammation Research; Medical Research Council; University of Edinburgh
- Tian FuCentral South University; Third Xiangya Hospital
- Minzi DengCentral South University; Third Xiangya Hospital
- Han ZhangSecond Affiliated Hospital of Zhejiang University
Abstract
Background and aims
Ultra-processed food [UPF] consumption has been linked to globally increasing incidence and prevalence of chronic diseases, including inflammatory bowel diseases [IBD]. We aimed to investigate the association between UPF consumption and IBD incidence, prevalence, and IBD-relevant outcomes.
Methods
We performed a cross-sectional and prospective cohort study in 187 854 individuals included in the national UK Biobank, using 24-h dietary recall questionnaires. Multivariable logistic regression and Cox proportional hazard regression were used to examine the association between UPFs and the prevalence and incidence risk of IBD, respectively.
Results
A total of 185 849 participants with a mean age of 56.2 were included, with a mean follow-up of 9.84 years. During follow-up, 841 developed IBD (251 Crohn's disease [CD], and 590 ulcerative colitis [UC]). UPF intake in IBD patients was significantly higher: CD: odds ratio [OR] 1.94 (95% confidence interval [CI]: 1.52, 2.49, p <0.001); UC: OR 1.39 [95% CI: 1.17, 1.65, p <0.001]. Compared with low consumption, higher UPF consumption was significantly associated with incident CD: hazard ration [HR] 2.00 [95% CI: 1.32, 3.03, p = 0.001], but not UC. We also found a significant association between UPF intake and need of IBD-related surgery: HR 4.06 [95% CI: 1.52, 10.86, p = 0.005].
Conclusion
Higher intake of UPFs was associated with higher incidence of CD, but not UC. In individuals with a pre-existing diagnosis of IBD, consumption of UPFs was significantly higher compared with controls, and was associated with an increased need for IBD-related surgery. Further studies are needed to address the impact of UPF intake on disease pathogenesis and outcomes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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