Funded in part by Novo Nordisk Fonden
Unprocessed red meat in the dietary treatment of obesity: a randomized controlled trial of beef supplementation during weight maintenance after successful weight loss
Magkos F, Rasmussen SI, Hjorth MF, Asping S, Rosenkrans MI, Sjödin AM, Astrup AV, Geiker NRW
The American journal of clinical nutrition · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- University or hospital
- Københavns Universitet
- Company
- Novo Nordisk Fonden
Based on 2 listed funder(s).
Publication
- Published
- 2022-08-24 · Am J Clin Nutr · vol. 116 · issue 6 · pp. 1820–1830
- Publisher
- Elsevier BV
- Cited
- 8 citations · more than 74% of similar papers · 0.9× the field average
- References
- 41 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Agriculture Sustainability and Environmental Impact · Meat and Animal Product Quality · Nutritional Studies and Diet
- Keywords
- Weight loss, Obesity, Randomized controlled trial, Medicine, Animal science, Food science, Biology, Internal medicine
- MeSH
- animals, cattle, humans, obesity, weight loss, diet, body composition, dietary supplements, adult, female, male, red meat, body weight maintenance
8 authors
From DK
- Faidon Magkos · correspondingUniversity of Copenhagen
- Sidse Ida Ingemann RasmussenUniversity of Copenhagen
- Mads F. HjorthUniversity of Copenhagen
- Sarah AspingUniversity of Copenhagen
- Maria I. RosenkransUniversity of Copenhagen
- Anders Mikael SjödinUniversity of Copenhagen
Abstract
Background
Consumption of unprocessed red meat in randomized trials has no adverse effects on cardiovascular risk factors and body weight, but its physiological effects during weight loss maintenance are not known.
Objectives
We sought to investigate the effects of healthy diets that include small or large amounts of red meat on the maintenance of lost weight after successful weight loss, and secondarily on body composition (DXA), resting energy expenditure (REE; indirect calorimetry), and cardiometabolic risk factors.
Methods
In this 5-mo parallel randomized intervention trial, 108 adults with BMI 28-40 kg/m2 (45 males/63 females) underwent an 8-wk rapid weight loss period, and those who lost ≥8% body weight (n = 80) continued to ad libitum weight maintenance diets for 12 wk: a moderate-protein diet with 25 g beef/d (B25, n = 45) or a high-protein diet with 150 g beef/d (B150, n = 35).
Results
In per protocol analysis (n = 69), mean body weight (-1.2 kg; 95% CI: -2.1, -0.3 kg), mean fat mass (-2.7 kg; 95% CI: -3.4, -2.0 kg), and mean body fat content (-2.6%; 95% CI: -3.1, -2.1%) decreased during the maintenance phase, whereas mean lean mass (1.5 kg; 95% CI: 1.0, 2.0 kg) and mean REE (51 kcal/d; 95% CI: 15, 86 kcal/d) increased, with no differences between groups (all P > 0.05). Results were similar in intention-to-treat analysis with multiple imputation for dropouts (20 from B150 compared with 19 from B25, P = 0.929). Changes in cardiometabolic risk factors were not different between groups, the general pattern being a decrease during weight loss and a return to baseline during weight maintenance (and despite the additional mild reduction in weight and fat mass).
Conclusions
Healthy diets consumed ad libitum that contain a little or a lot of unprocessed beef have similar effects on body weight, energy metabolism, and cardiovascular risk factors during the first 3 mo after clinically significant rapid weight loss.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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