Immediate Effect in the Retina and Choroid after 650 nm Low-Level Red Light Therapy in Children
Yang W, Lin F, Li M, Wei R, Zhou J, Zhou X
Ophthalmic research · 26 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Shanghai Rising-Star Program
- Grants
- National Natural Science Foundation of China (81770955); National Natural Science Foundation of China (SHDC12018103); National Natural Science Foundation of China (20410710100); Shanghai Rising-Star Program (21QA1401500)
Based on 2 listed funder(s).
Publication
- Published
- 2022-10-31 · Ophthalmic Res · vol. 66 · issue 1 · pp. 312–318
- Publisher
- Karger Publishers
- Cited
- 35 citations · more than 93% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 33 works
- Access
- Open access (free to publish) · CC-BY-NC
- Research areas
- Laser Applications in Dentistry and Medicine · Ophthalmology and Visual Impairment Studies · Retinal Diseases and Treatments
- Keywords
- Ophthalmology, Choroid, Retinal, Medicine, Retina, Optical coherence tomography, Significant difference, Fluorescein angiography, Mean difference, Confidence interval, Optics, Internal medicine, Physics
- MeSH
- retina, choroid, humans, tomography, optical coherence, prospective studies, child, china, red light
6 authors
From CN
- Weiming YangChinese Academy of Medical Sciences & Peking Union Medical College; Fudan University; Shanghai Eye Disease Prevention & Treatment Center; Eye & ENT Hospital of Fudan University; Shanghai Clinical Research Center; Children's Hospital of Fudan University
- Feng LinChinese Academy of Medical Sciences & Peking Union Medical College; Fudan University; Shanghai Eye Disease Prevention & Treatment Center; Eye & ENT Hospital of Fudan University; Shanghai Clinical Research Center
- Meiyan LiChinese Academy of Medical Sciences & Peking Union Medical College; Fudan University; Shanghai Eye Disease Prevention & Treatment Center; Eye & ENT Hospital of Fudan University; Shanghai Clinical Research Center
- Ruoyan WeiChinese Academy of Medical Sciences & Peking Union Medical College; Fudan University; Shanghai Eye Disease Prevention & Treatment Center; Eye & ENT Hospital of Fudan University; Shanghai Clinical Research Center
- Jiaqi ZhouChinese Academy of Medical Sciences & Peking Union Medical College; Fudan University; Shanghai Eye Disease Prevention & Treatment Center; Eye & ENT Hospital of Fudan University; Shanghai Clinical Research Center
- Xingtao ZhouChinese Academy of Medical Sciences & Peking Union Medical College; Fudan University; Shanghai Eye Disease Prevention & Treatment Center; Eye & ENT Hospital of Fudan University; Shanghai Clinical Research Center
Abstract
Introduction
The objective of this study was to investigate the changes in the retina and choroid of children after 650 nm low-level red light therapy (LLRLT).
Methods
In this prospective study, 25 subjects in the Shanghai Eye and ENT Hospital of Fudan University were included from August 2021 to September 2021. One eye was randomly selected to receive LLRLT for 3 min. Swept-source optical coherence tomography (OCT) and OCT angiography were used to measure retinal fovea perfusion density (RFPD), retinal fovea thickness (RFT), choroidal fovea blood flow (CFBF), and choroidal fovea thickness (CFT) before LLRLT, 5 min and 1 h after LLRLT. Baseline characteristics between LLRLT and non-LLRLT eyes were compared. Changes in the retinal and choroidal parameters were analyzed by ANCOVA models. SAS software was used for data analysis. The difference was considered statistically significant if p < 0.05.
Results
There was no difference in baseline characteristics between LLRLT eyes and non-LLRLT eyes. The RFPD in LLRLT eyes significantly increased 5 min after LLRLT, and the increment was 1.70 ± 0.83% (p = 0.0389). The RFPD significantly decreased from 5 min to 1 h after LLRLT with a mean of -2.62 ± 0.86% decrement (p = 0.0031). The RFPD levels returned to baseline at 1 h after LLRLT (p = 0.8646). However, compared with insignificant RFPD changes in non-LLRLT eyes, there was no significant difference in RFPD changes at any sampling point. No significant changes in RFT, CFBF, and CFT were found in LLRLT eyes at each sampling point.
Conclusion
Although 3 min of LLRLT has no effect on the choroid, it may cause a short-term transient increase in RFPD. It will provide theoretical support for the role of LLRLT in myopia control.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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