Beneficial effect of time-restricted eating on blood pressure: a systematic meta-analysis and meta-regression analysis
Wang W, Wei R, Pan Q, Guo L
Nutrition & metabolism · 31 citations
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (82170848)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-11-08 · Nutr Metab (Lond) · vol. 19 · issue 1 · p. 77
- Publisher
- BioMed Central
- Cited
- 39 citations · more than 94% of similar papers · 3.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Enhanced Recovery After Surgery · Circadian rhythm and melatonin
- Keywords
- Blood pressure, Medicine, Meta-analysis, Cochrane Library, Internal medicine, Meta-regression, Clinical nutrition, Heart rate, Cardiology, Surgery
4 authors
From CN
- Weihao WangChinese Academy of Medical Sciences & Peking Union Medical College
- Ran WeiChinese Academy of Medical Sciences & Peking Union Medical College; Peking University
- Qi Pan · correspondingChinese Academy of Medical Sciences & Peking Union Medical College
- Lixin Guo · correspondingChinese Academy of Medical Sciences & Peking Union Medical College; Peking University; Peking University People's Hospital
Abstract
Background
As a cardiometabolic disease, hypertension has shown an obvious upward trend, becoming a global epidemic chronic disease. Lifestyle intervention is a fundamental method for lowering blood pressure. This systematic review and meta-analysis aimed to evaluate the effects of time-restricted eating (TRE) on blood pressure.
Methods
Studies were retrieved from the PubMed, Embase, Cochrane Library, and Web of Science databases to evaluate the effects of TRE on blood pressure. The time frame of search was from the start of database construction until July 14, 2022.There were no language restrictions. Meta-analysis and meta-regression were performed using Stata version 16. The weighted mean difference with 95% CI was used to assess the effect of TRE on blood pressure, heart rate, weight, blood glucose, total cholesterol, HDL-C, LDL-C, and triglycerides. The main ending of this article were blood pressure and heart rate, while the secondary ending were weight, blood glucose, total cholesterol, HDL-C, LDL-C, and triglycerides.
Results
Ten randomized controlled trials involving 694 patients were identified. TRE significantly reduced systolic blood pressure (SBP) (mean difference = -4.15; 95% CI: -6.73, -2.30; P < 0.0001), but had no significant effect on diastolic blood pressure (DBP) (mean difference = -2.06; 95% CI: -4.16, 0.02; P = 0.053) and no beneficial effect on heart rate (mean difference = 0.36; 95% CI: -2.83, 3.54; P = 0.0825). TRE promoted weight loss (mean difference = -1.63; 95% CI: -2.61, -0.64; P = 0.001) and decreased blood glucose levels (mean difference = -2.80; 95% CI: -4.64, -0.96; P = 0.003), but had no significant effect on total cholesterol (mean difference = 0.03, 95% CI: -10.01, 10.08; P = 0.995), HDL-C (mean difference = 0.85, 95% CI: -1.80, 3.49; P = 0.531), LDL-C (mean difference = -0.86, 95% CI: -6.47, 4.76; P = 0.764), or triglycerides (mean difference = -3.524, 95% CI: -9.49, 2.45; P = 0.248). In a separate meta-regression analysis, the degree of SBP change was related to weight loss (P = 0.044) but not to glucose improvement (P = 0.867).
Conclusions
The present meta-analysis suggests that TRE significantly reduced SBP, while no effect of reducing DBP was seen. The observed lower blood pressure may be attributed to significant weight loss. The effects of TRE on heart rate and blood lipid levels were not apparent.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.