Phytochemistry, allelopathy and anticancer potentiality of Withania somnifera (L.) Dunal (Solanaceae)
Ahmed HA, El-Darier SM
Brazilian journal of biology = Revista brasleira de biologia · 4 citations
Review labels
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How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- King Faisal University
Based on 1 listed funder(s).
Publication
- Published
- 2022-11-04 · Braz J Biol · vol. 84 · p. e263815
- Publisher
- Instituto Internacional de Ecologia (Brazil)
- Cited
- 17 citations · more than 94% of similar papers · 4.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Phytochemicals and Medicinal Plants · Essential Oils and Antimicrobial Activity · Ethnobotanical and Medicinal Plants Studies
- Keywords
- Withania somnifera, Biology, Allelopathy, Cell culture, Traditional medicine, Botany, Glycoside, Germination
- MeSH
- caco-2 cells, humans, solanaceae, withania, vegetables, carcinoma, non-small-cell lung, lung neoplasms, plant extracts, allelopathy
2 authors
From SA, EG
- Hoda AhmedKing Faisal University; Alexandria University
- Salama Mohamed El-DarierAlexandria University
Abstract
Withania somnifera is a wild plant that shows great activity and safety against several human diseases. The current research explored the plant's chemical composition and allelopathic effects on Rumex dentatus (recipient plant). Moreover, anticancer activity is also tested against four types of human cancer cell lines. Chemical analysis of W. somnifera showed a high percentage of saponins and tannins, while glycosides, alkaloids, and flavonoids occurred in the second order. Results of the allelopathic experiments revealed significant inhibition of the R. dentatus plumule and radicle lengths as well as their relative dry weights. In addition, significant reductions in some primary metabolites of R. dentatus, like non-reducing and total sugar as well as soluble proteins, were determined. Cytotoxic potentiality of W. somnifera was also proved against four different cancer lines, namely; human hepatocellular carcinoma cell line (HepG2), human non-small cell lung cancer cell line (A549), human breast cancer cell line (MCF7), and colon cancer cell line (CaCo2) with IC50 value of about 38, 19, 27, and 24 𝜇g/ml, respectively.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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