Time restricted feeding modifies leukocyte responsiveness and improves inflammation outcome
Ella K, Sűdy ÁR, Búr Z, Koós B, Kisiczki ÁS, Mócsai A, Káldi K
Frontiers in immunology · 24 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Semmelweis Egyetem
- Government
- Emberi Eroforrások Minisztériuma
- Government
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- Government
- Innovációs és Technológiai Minisztérium
- Government
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap
- Government
- National Research, Development and Innovation Office
- Grants
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap (TKP2021-EGA); Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (TKP2021); Innovációs és Technológiai Minisztérium (TKP2021-EGA); Innovációs és Technológiai Minisztérium (NKP-20-4); Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (TKP2021-EGA-25); Semmelweis Egyetem (TKP2021‐EGA‐24); National Research, Development and Innovation Office (TKP2021-EGA25); Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (NKP-20-4-II); Innovációs és Technológiai Minisztérium (TKP2021‐EGA‐24); Nemzeti Kutatási, Fejlesztési és Innovaciós Alap (TKP2021‐EGA‐24); Nemzeti Kutatási, Fejlesztési és Innovaciós Alap (TKP2021); National Research, Development and Innovation Office (TKP-2021-EGA); Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (TKP2021-EGA-24); National Research, Development and Innovation Office (TKP2021-EGA-24); Semmelweis Egyetem (STIA-2017); Innovációs és Technológiai Minisztérium (TKP2021); National Research, Development and Innovation Office (K115953); Semmelweis Egyetem (TKP2021); Innovációs és Technológiai Minisztérium (TKP2021-EGA-25); Nemzeti Kutatási, Fejlesztési és Innovaciós Alap (TKP2021-EGA25); Semmelweis Egyetem (TKP 2021 EGA-25); Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (TKP2021-EGA); National Research, Development and Innovation Office (TKP 2021); Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (K115953); Semmelweis Egyetem (STIA-2018); National Research, Development and Innovation Office (K132393); Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (K132393)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-11-02 · Front Immunol · vol. 13 · p. 924541
- Publisher
- Frontiers Media
- Cited
- 31 citations · more than 92% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 75 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Sleep and related disorders
- Keywords
- Inflammation, Circadian rhythm, Immune system, Endocrinology, Adipose tissue, Internal medicine, Immunology, Systemic inflammation, Circadian clock, Entrainment (biomusicology), Arthritis, Medicine, Biology, Rhythm
- MeSH
- leukocytes, animals, humans, mice, obesity, inflammation, fasting, eating
7 authors
From HU
- Krisztina Ella · correspondingSemmelweis University
- Ágnes Réka SűdySemmelweis University
- Zsófia BúrSemmelweis University
- Bence KoósSemmelweis University
- Ármin S. KisiczkiSemmelweis University
- Attila MócsaiSemmelweis University
Abstract
Time restricted eating, the dietary approach limiting food intake to a maximal 10-hour period of daytime is considered beneficial in metabolic dysfunctions, such as obesity and diabetes. Rhythm of food intake and parallel changes in serum nutrient levels are also important entrainment signals for the circadian clock, particularly in tissues involved in metabolic regulation. As both the metabolic state and the circadian clock have large impact on immune functions, we investigated in mice whether time restricted feeding (TRF) affects systemic inflammatory potential. TRF slackened the symptoms in K/BxN serum-transfer arthritis, an experimental model of human autoimmune joint inflammation. Compared to ad libitum conditions TRF reduced the expression of inflammatory mediators in visceral adipose tissue, an integrator and coordinator of metabolic and inflammatory processes. Furthermore, TRF strengthened the oscillation of peripheral leukocyte counts and alongside decreased the pool of both marginated and tissue leukocytes. Our data suggest that the altered leukocyte distribution in TRF mice is related to the attenuated expression of adhesion molecules on the surface of neutrophils and monocytes. We propose that TRF modifies both rhythm and inflammatory potential of leukocytes which contribute to the milder reactivity of the immune system and therefore time-restricted eating could serve as an effective complementary tool in the therapy of autoinflammatory processes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.