Systematic review2022Open access

Time-restricted eating for patients with diabetes and prediabetes: A systematic review

Lin X, Guan Y, Wu G, Huang J, Wang S

Frontiers in nutrition · 6 citations

How it was studied

Design
Systematic review (indexed by PubMed)
Studied in
People
Main outcome
Health markers and function

Who paid for it

Funding
Independent funding
Government
China Postdoctoral Science Foundation

Based on 1 listed funder(s) and full-text disclosure statement.

Publication

Published
2022-11-03 · Front Nutr · vol. 9 · p. 1025919
Publisher
Frontiers Media
Cited
12 citations · more than 46% of similar papers · 0.4× the field average
References
25 works
Access
Open access (journal) · CC-BY
Research areas
Dietary Effects on Health · Enhanced Recovery After Surgery · Circadian rhythm and melatonin
Keywords
Prediabetes, Medicine, Diabetes mellitus, Weight loss, Systematic review, MEDLINE, Insulin sensitivity, Internal medicine, Type 2 diabetes, Intensive care medicine, Insulin resistance, Endocrinology, Obesity

5 authors

From CN

  • Xiaoxiao LinZhejiang Chinese Medical University
  • Yihong GuanZhejiang Chinese Medical University
  • Guomin WuAffiliated Hangzhou First People's Hospital, Westlake University, School of Medicine; Zhejiang University
  • Jinyu Huang · correspondingAffiliated Hangzhou First People's Hospital, Westlake University, School of Medicine; Zhejiang University
  • Shuai Wang · correspondingAffiliated Hangzhou First People's Hospital, Westlake University, School of Medicine; Zhejiang University

Abstract

Background

Several studies have explored the effect of time-restricted eating (TRE) on patients with diabetes and prediabetes. However, these studies have not been analyzed and summarized as a whole. We conducted a systematic review to summarize and analyze all studies about the efficacy and safety of TRE for patients with diabetes and prediabetes.

Methods

We conducted a comprehensive search of the Embase, PubMed and Cochrane databases and the time span was from inception to 1 May 2022. The Cochrane Collaboration's Risk of Bias 2 (RoB2) and ROBINS-I tools were used to evaluate the quality of included studies. The effect of TRE on weight loss, insulin sensitivity, plasma glucose, and the safety of TRE were summarized and analyzed.

Results

In total, 7 studies with 326 participants including 5 articles with 217 patients with diabetes and 2 articles with 109 patients with prediabetes were included. The TRE windows were from 4 to 10 h. The percentages of females ranged from 0 to 90%. The mean age ranged from 35.2 to 67.5 years, and most of patients adhered to TRE. All studies were assessed as high quality. TRE may result in weight loss, and improvements in the insulin sensitivity and plasma glucose, with no severe AEs.

Conclusion

Time-restricted eating is a safe and feasible intervention, and may offer cardiovascular and metabolic benefits for patients with diabetes and prediabetes. Studies in this field, which should be viewed as important, are limited. Therefore, more high-quality studies are needed.

Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).

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