Dietary cholesterol consumption and incidence of type 2 diabetes mellitus: A dose-response meta-analysis of prospective cohort studies
Li Y, Pei H, Zhou C, Lou Y
Nutrition, metabolism, and cardiovascular diseases : NMCD · 9 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Peking Union Medical College
- Government
- Fundamental Research Funds for the Central Universities
- Grants
- National Natural Science Foundation of China (81970290); Fundamental Research Funds for the Central Universities (2017320009); National Natural Science Foundation of China (81760096)
Based on 3 listed funder(s).
Publication
- Published
- 2022-08-31 · Nutr Metab Cardiovasc Dis · vol. 33 · issue 1 · pp. 2–10
- Publisher
- Elsevier BV
- Cited
- 15 citations · more than 61% of similar papers · 0.7× the field average
- References
- 38 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins · Consumer Attitudes and Food Labeling
- Keywords
- Medicine, Subgroup analysis, Prospective cohort study, Meta-analysis, Type 2 Diabetes Mellitus, Incidence (geometry), Internal medicine, Type 2 diabetes, Confidence interval, Relative risk, Random effects model, Diabetes mellitus, Cohort study, Demography, Endocrinology, Mathematics
- MeSH
- humans, diabetes mellitus, type 2, cholesterol, dietary, incidence, risk factors, prospective studies
4 authors
From CN
- Yuehua LiChinese Academy of Medical Sciences & Peking Union Medical College
- Hanjun PeiBaotou Medical College
- Chenghui ZhouChinese Academy of Medical Sciences & Peking Union Medical College
- Ying Lou · correspondingChinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital
Abstract
Background and aim
The purpose of this meta-analysis was to evaluate the dose-response relationship between dietary cholesterol (DC) consumption and the incidence of type 2 diabetes mellitus (T2DM).
Methods and results
Prospective studies with the endpoint of T2DM were included. The Random-effect model weighted by inverse variance was used. Meta-regression and subgroup analyses were conducted to explore the potential sources of heterogeneity by specified study characteristics. Restricted cubic splines regression models were used to estimate the dose-response relationship. 11 prospective studies comprising of 355 230 subjects were included. Compared to lowest DC consumption, highest DC consumption was associated with an increased risk of T2DM (RR 1.15, 95% CI 1.03 to 1.28, P = 0.012; chi-squared = 31.41, I-squared 58.6%, P heterogeneity = 0.003). Subgroup analyses have shown that this positive association was more evident in western countries than in eastern countries (RR 1.19, 95% CI 1.06 to 1.36 VS 1.34, 95% CI 0.84 to 1.29; P subgroup difference = 0.02). For 100 mg/d increment in DC intake, the pooled RR was 1.05, (95% CI 1.04 to 1.07, Plinearity = 0.000, Pnonlinearity = 0.02), 1.06 (95% CI 1.04 to 1.07, Plinearity=0.000), and 1.01 (95% CI 0.98 to 1.05, Plinearity = 0.525) for the incidence of T2DM, in western and eastern countries, respectively.
Conclusions
Our study suggests that there is a positive dose-response association between DC consumption and the incidence of T2DM, especially in western countries.
Systematic review registration
PROSPERO CRD42020216318.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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