Funded in part by Abiogen Pharma, Pisa, Italy
Effects on Serum Inflammatory Cytokines of Cholecalciferol Supplementation in Healthy Subjects with Vitamin D Deficiency
Fassio A, Gatti D, Rossini M, Bertelle D, Bixio R, Viapiana O, Milleri S, Benini C, Pistillo F, Zanetti G, Adami G
Nutrients · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Industry funded
- Company
- Abiogen Pharma, Pisa, Italy
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-11-14 · Nutrients · vol. 14 · issue 22 · p. 4823
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 10 citations · more than 79% of similar papers · 1.2× the field average
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Microscopic Colitis · Urticaria and Related Conditions
- Keywords
- Cholecalciferol, Medicine, Vitamin D and neurology, Internal medicine, vitamin D deficiency, Dosing, Vitamin, Endocrinology, Proinflammatory cytokine, Gastroenterology, Inflammation
- MeSH
- humans, vitamin d deficiency, cholecalciferol, vitamins, vitamin d, tumor necrosis factor-alpha, interleukin-8, interleukin-6, interleukin-10, interleukin-17, cytokines, dietary supplements, adult, female, male, interleukin-23, young adult, healthy volunteers
11 authors
From IT
- Angelo FassioUniversity of Verona
- Davide GattiUniversity of Verona
- Maurizio RossiniUniversity of Verona
- Davide Bertelle · correspondingUniversity of Verona
- Riccardo BixioUniversity of Verona
- Ombretta ViapianaUniversity of Verona
Abstract
The effects of different cholecalciferol supplementation regimens on serum inflammatory cytokines in healthy subjects with vitamin D deficiency are still lacking. This is a single-center, open-label, randomized, parallel group study involving healthy subjects deficient in vitamin D (baseline 25OHD < 20 ng/mL) receiving oral cholecalciferol with three different dosing regimens: Group A: 10,000 IU/day for 8 weeks followed by 1000 IU/day for 4 weeks; Group B: 50,000 IU/week for 12 weeks and Group C: 100,000 IU every other week for 12 weeks. IL-17A, IL-6, IL-8, IL-10, IL-23 and TNFα were measured at baseline and at week 4, 8, 12, and 16. 75 healthy subjects were enrolled (58.7% female), with an average age of 34.1 ± 10.2 years. No statistical differences were observed among groups at baseline for either IL-6, IL-17A, IL-23, IL-8 or IL-10 at any time point; TNFα was indetectable. Concerning the whole sample, the time trend analysis showed a statistically significant linear trend for decreasing values over the treatment period for IL-6 (p = 0.016) and IL-17A (p = 0.006), while no significant time trends were observed for the other teste cytokines. No significant differences were found in the serum concentrations of the tested cytokines between week 12 and week 16. In young healthy individuals deficient in vitamin D, cholecalciferol administration showed a decrease in the serum IL-6 and IL-17A concentrations, without marked differences using the three regimens.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.