The Association between Dietary Magnesium Intake and Telomere Length in Adults with Hypertension
Zhao G, Guo D, Li L, Yang C, Dong J
The journal of nutrition, health & aging · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-11-01 · J Nutr Health Aging · vol. 26 · issue 11 · pp. 1010–1015
- Publisher
- Springer Science+Business Media
- Cited
- 6 citations · more than 67% of similar papers · 0.7× the field average
- References
- 45 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Telomeres, Telomerase, and Senescence · Menopause: Health Impacts and Treatments · Birth, Development, and Health
- Keywords
- National Health and Nutrition Examination Survey, Medicine, Telomere, Micronutrient, Magnesium, Bayesian multivariate linear regression, Internal medicine, Physiology, Endocrinology, Linear regression, Environmental health, Biology, Population, Chemistry, Pathology, Biochemistry
- MeSH
- telomere, humans, hypertension, magnesium, uric acid, nutrition surveys, female, male
5 authors
From CN
- Ge ZhaoFirst Affiliated Hospital of Zhengzhou University
- Danfeng GuoFirst Affiliated Hospital of Zhengzhou University
- L. LiFirst Affiliated Hospital of Zhengzhou University
- Chih‐Wei YangFirst Affiliated Hospital of Zhengzhou University
- Jianzeng Dong · correspondingCapital Medical University; Beijing Anzhen Hospital; First Affiliated Hospital of Zhengzhou University
Abstract
Background
Dietary micronutrients are significantly associated with telomere length, as shown in multiple studies. However, no study has investigated the association between magnesium intake and telomere length in adults with hypertension.
Methods
Participants were included from the National Health and Nutrition Examination Survey (NHANES) in 1999-2000 and 2001-2002. Dietary magnesium intake was assessed using the 24 - hour recall method and the telomere length of leukocytes was measured using polymerase chain reaction (PCR). A multivariate regression model was then used to assess the association between dietary magnesium intake and telomere length in adults with hypertension.
Results
Our final analysis included 2199 hypertensive adults (46.79% males) with a mean dietary magnesium intake of 254.82±133.47 mg/day. Linear regression, adjusted for race, sex, age, smoking, uric acid, and other variables, showed that every 1 mg increase in dietary magnesium intake was associated with a 0.20 (95% CI: 0.01, 0.39, p = 0.043) longer telomere length in all participants. In the ≥45 years age group, there was a statistically significant association between the telomere length and dietary magnesium (95% CI: 0.16, 0.63, p <0.001).
Conclusions
This study suggests that increased magnesium intake is associated with a longer telomere length in hypertensive adults, especially in those ≥45 years of age. However, further research is needed to determine a causal relationship.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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