Lipolysis-derived linoleic acid drives beige fat progenitor cell proliferation
Abe I, Oguri Y, Verkerke ARP, Monteiro LB, Knuth CM, Auger C, Qiu Y, Westcott GP, Cinti S, Shinoda K, Jeschke MG, Kajimura S
Developmental cell · 49 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Howard Hughes Medical Institute
- Nonprofit
- Uehara Memorial Foundation
- Nonprofit
- Japan Heart Foundation
- Government
- National Institutes of Health
- University or hospital
- University of California, San Diego
- Government
- Japan Society for the Promotion of Science
- Government
- National Institute of General Medical Sciences
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Government
- NIGMS NIH HHS
- Government
- NIH HHS
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007516); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK135043); Japan Society for the Promotion of Science (23K24766); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK133948); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK125281); National Institute of Diabetes and Digestive and Kidney Diseases (K08 DK132413); Uehara Memorial Foundation (T32DK007516); National Institute of Diabetes and Digestive and Kidney Diseases (DP1 DK126160); National Institute of General Medical Sciences (R01 GM133961); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK097441); National Institutes of Health (1s10od028635-01); National Institutes of Health (#R01GM133961); National Institutes of Health (RO1DK125281); National Institutes of Health (DP1DK126160)
Based on 11 listed funder(s).
Publication
- Published
- 2022-12-01 · Dev Cell · vol. 57 · issue 23 · pp. 2623–2637.e8
- Publisher
- Elsevier BV
- Cited
- 56 citations · more than 97% of similar papers · 5.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 78 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Adipose Tissue and Metabolism · Fatty Acid Research and Health · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Biology, Progenitor cell, Cell biology, Linoleic acid, CD36, Adipose tissue, Lipolysis, Arachidonic acid, Endocrinology, Internal medicine, Fatty acid, Biochemistry, Stem cell, Receptor
- MeSH
- animals, humans, mice, linoleic acid, cell proliferation, adipose tissue, beige
12 authors
From US, JP, CA, IT
- Ichitaro AbeBeth Israel Deaconess Medical Center; Harvard University; Oita University
- Yasuo OguriKyoto University
- Anthony R.P. VerkerkeBeth Israel Deaconess Medical Center; Harvard University
- Lauar de Brito MonteiroSunnybrook Health Science Centre; University of Toronto; Sunnybrook Hospital; Sunnybrook Research Institute
- Carly M. KnuthSunnybrook Health Science Centre; University of Toronto; Sunnybrook Hospital; Sunnybrook Research Institute
- Christopher AugerBeth Israel Deaconess Medical Center; Harvard University
Abstract
De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white adipose tissue (WAT); however, what regulates this process remains unclear. Here, we report that in mouse models but also in human tissues, WAT lipolysis-derived linoleic acid triggers beige progenitor cell proliferation following cold acclimation, β3-adrenoceptor activation, and burn injury. A subset of adipocyte progenitors, as marked by cell surface markers PDGFRα or Sca1 and CD81, harbored cristae-rich mitochondria and actively imported linoleic acid via a fatty acid transporter CD36. Linoleic acid not only was oxidized as fuel in the mitochondria but also was utilized for the synthesis of arachidonic acid-derived signaling entities such as prostaglandin D2. Oral supplementation of linoleic acid was sufficient to stimulate beige progenitor cell proliferation, even under thermoneutral conditions, in a CD36-dependent manner. Together, this study provides mechanistic insights into how diverse pathophysiological stimuli, such as cold and burn injury, promote de novo beige fat biogenesis.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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