Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study
Luo J, Zhang C, Zhao Q, Wu W, Liang X, Xiao Z, Mortimer JA, Borenstein AR, Dai Q, Ding D
Alzheimer's & dementia (New York, N. Y.) · 15 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Shanghai Hospital Development Center
- Government
- National Institute on Aging
- Government
- NIA NIH HHS
- Grants
- Shanghai Hospital Development Center (SHDC2020CR4007); National Natural Science Foundation of China (81773513); National Institute on Aging (R21 AG028182); National Natural Science Foundation of China (82071200)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-01-01 · Alzheimers Dement (N Y) · vol. 8 · issue 1 · p. e12362
- Publisher
- Elsevier BV
- Cited
- 21 citations · more than 86% of similar papers · 1.9× the field average
- References
- 36 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Trace Elements in Health
- Keywords
- Dementia, Hazard ratio, Medicine, Calcium, Magnesium, Internal medicine, Confidence interval, Prospective cohort study, Incidence (geometry), Chemistry, Disease
10 authors
From CN, KR, US
- Jianfeng LuoFudan University; Ministry of Education
- Chenbo ZhangFudan University; Ministry of Education
- Qianhua ZhaoFudan University; Huashan Hospital
- Wanqing WuFudan University; Huashan Hospital
- Xiaoniu LiangFudan University; Huashan Hospital
- Zhenxu XiaoFudan University; Huashan Hospital
Abstract
Introduction
Calcium (Ca), magnesium (Mg), or the calcium to magnesium (Ca:Mg) ratio may affect the risk of dementia via complex mechanisms. The aim of this study was to evaluate the association of dietary Ca, Mg, and Ca:Mg ratio with dementia risk at the prospective phase of the Shanghai Aging Study.
Methods
We analyzed data from 1565 dementia-free participants living in an urban community who had measurements of dietary Ca and Mg intake derived from a food frequency questionnaire at baseline and incident dementia during follow-up.
Results
Over the 5-year follow-up, 162 (10.4%) participants were diagnosed with incident dementia by Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria. Participants with the lowest tertile of dietary Ca (267.5 mg/day was related to an increased risk for dementia (adjusted hazard ratio: 3.97, 95% confidence interval: 1.29-12.25).
Conclusions
Our findings suggest that high dietary intake of Mg is associated with an increased risk of dementia mainly among older adults with low Ca:Mg intake ratios. Proper balance of Ca to Mg in the diet may be critical to the relationship between Mg intake and risk of dementia.
Highlights
Participants with the lowest tertile of dietary calcium (Ca) and magnesium (Mg) had the highest incidence rates of dementia.In the subgroup with Ca:Mg ratios ≤1.69, Mg intake >267.5 mg/day was related to an increased risk for dementia.Balance of Ca to Mg in diet may be critical to the relationship between Mg intake and risk of dementia.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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