Randomized controlled trial2023

Early time-restricted eating affects weight, metabolic health, mood, and sleep in adherent completers: A secondary analysis

Steger FL, Jamshed H, Bryan DR, Richman JS, Warriner AH, Hanick CJ, Martin CK, Salvy SJ, Peterson CM

Obesity (Silver Spring, Md.) · 62 citations

How it was studied

Design
Randomized controlled trial (indexed by PubMed)
Studied in
People
Main outcome
Health markers and function

Who paid for it

Funding
Independent funding
Government
National Heart, Lung, and Blood Institute
Government
National Institute of General Medical Sciences
Government
National Institute of Diabetes and Digestive and Kidney Diseases
Government
National Center for Advancing Translational Sciences
Government
NIDDK NIH HHS
Government
NCATS NIH HHS
Government
NIGMS NIH HHS
Government
NHLBI NIH HHS
Grants
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626); National Institute of General Medical Sciences (U54‐ GM104940); National Heart, Lung, and Blood Institute (T32HL105349)); National Center for Advancing Translational Sciences (KL2 TR001419); National Center for Advancing Translational Sciences (TL1 TR001418); National Center for Advancing Translational Sciences (UL1 TR001418); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-072476); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-056336)

Based on 8 listed funder(s).

Publication

Published
2022-12-14 · Obesity (Silver Spring) · vol. 31 · issue S1 · pp. 96–107
Publisher
Wiley
Cited
73 citations · more than 98% of similar papers · 6.1× the field average
Impact
Top 10% most cited in its field
References
47 works
Access
Open access (repository copy)
Research areas
Dietary Effects on Health · Enhanced Recovery After Surgery · Circadian rhythm and melatonin
Keywords
Medicine, Weight loss, Mood, Anger, Obesity, Internal medicine, Heart rate, Body weight, Randomized controlled trial, Physical therapy, Endocrinology, Blood pressure, Psychiatry
MeSH
humans, cardiovascular diseases, obesity, weight loss, fasting, sleep, body composition, eating, adult, aged, middle aged

9 authors

From US, PK

  • Felicia L. StegerUniversity of Alabama at Birmingham; University of Kansas Medical Center
  • Humaira JamshedUniversity of Alabama at Birmingham; Habib University
  • David R. BryanUniversity of Alabama at Birmingham
  • Joshua RichmanUniversity of Alabama at Birmingham
  • Amy H. WarrinerUniversity of Alabama at Birmingham
  • Cody J. HanickUniversity of Alabama at Birmingham

Abstract

Objective

Data are mixed on whether intermittent fasting improves weight loss and cardiometabolic health. Here, the effects of time-restricted eating (TRE) in participants who consistently adhered ≥5 d/wk every week were analyzed.

Methods

Ninety patients aged 25 to 75 years old with obesity were randomized to early TRE (eTRE; 8-hour eating window from 07:00 to 15:00) or a control schedule (≥12-hour window) for 14 weeks. A per-protocol analysis of weight loss, body composition, cardiometabolic health, and other end points was performed.

Results

Participants who adhered to eTRE ≥5 d/wk every week had greater improvements in body weight (-3.7 ± 1.2 kg; p = 0.003), body fat (-2.8 ± 1.3 kg; p = 0.04), heart rate (-7 ± 3 beats/min; p = 0.02), insulin resistance (-2.80 ± 1.36; p = 0.047), and glucose (-9 ± 5 mg/dL; p = 0.047) relative to adherers in the control group. They also experienced greater improvements in mood, including fatigue and anger; however, they self-reported sleeping less and taking longer to fall asleep.

Conclusions

For those who can consistently adhere at least 5 d/wk, eTRE is a valuable approach for improving body weight, body fat, cardiometabolic health, and mood. Further research is needed to determine whether eTRE's effects of shortening sleep but reducing fatigue are healthful or not.

Abstract via Europe PMC. Copyright remains with the authors or publisher.

Community trust

Loading…

How much do you trust this study's findings?

0 · not at all10 · completely

Comments

Sign in to rate, comment on or flag this study.Sign in

Something wrong here?

Flag this study if its information, labels or funding look wrong. An editor reviews every flag.

Sign in to rate, comment on or flag this study.Sign in

Educational information about published research. Not medical advice, and not a recommendation to start or stop anything.