Nitrites, Nitrates, and Cardiovascular Outcomes: Are We Living "La Vie en Rose" With Pink Processed Meats?
Srour B, Chazelas E, Fezeu LK, Javaux G, Pierre F, Huybrechts I, Hercberg S, Deschasaux-Tanguy M, Kesse-Guyot E, Touvier M
Journal of the American Heart Association · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- World Health Organization
- Authors
- At least one author declares a financial tie to industry
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-12-19 · J Am Heart Assoc · vol. 11 · issue 24 · p. e027627
- Publisher
- Wiley
- Cited
- 21 citations · more than 82% of similar papers · 1.6× the field average
- References
- 18 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Sodium Intake and Health · Nitric Oxide and Endothelin Effects · Nutritional Studies and Diet
- Keywords
- Medicine, Hazard ratio, Cohort, Cohort study, Proportional hazards model, Nitrite, Population, Epidemiology, Internal medicine, Environmental health, Physiology, Confidence interval, Chemistry, Nitrate
- MeSH
- humans, cardiovascular diseases, hypertension, nitrates, nitrites, food additives, diet, meat, adult
10 authors
From FR
- Bernard SrourInserm; Université Paris Cité; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Centre de Recherche Épidémiologie et Statistique
- Eloi ChazelasInserm; Université Paris Cité; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Centre de Recherche Épidémiologie et Statistique
- Léopold FezeuInserm; Université Paris Cité; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Centre de Recherche Épidémiologie et Statistique
- Guillaume JavauxInserm; Université Paris Cité; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Centre de Recherche Épidémiologie et Statistique
- Fabrice H.F. PierreUniversité Toulouse III - Paul Sabatier; École Nationale Vétérinaire de Toulouse; Université Fédérale de Toulouse Midi-Pyrénées; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Toxicologie Alimentaire
- Inge HuybrechtsCentre international de recherche sur le cancer
Abstract
Background Nitrates and nitrites are used as food additives in processed meats. They are also commonly ingested from water and several foods. Several short-term clinical studies suggested beneficial effects of dietary nitrates on blood pressure, while deleterious effects on oxidative damage have been suggested in some experimental studies. However, there is a lack of evidence from longitudinal epidemiological studies linking foods and water-originated and additives-originated nitrites and nitrates, separately, to hypertension and cardiovascular diseases risk. We aimed to study these associations in a large population-based cohort. Methods and Results Overall, 106 288 adults from the French NutriNet-Santé cohort (2009-2022) were included. Associations between nitrites and nitrates intakes and hypertension and cardiovascular disease risks were assessed using multi-adjusted Cox proportional hazard models. During follow-up, 3810 incident cases of hypertension and 2075 cases of cardiovascular diseases were ascertained. Participants with higher intakes of additives-originated nitrites (sodium nitrite in particular [European code e250]) had a higher hypertension risk compared with nonconsumers (hazard ratio, 1.19 [95% CI, 1.08-1.32], P=0.001, and 1.19 [95% CI, 1.08-1.32], P=0.002), respectively. No association was detected between foods and water-originated nitrites, or nitrates with hypertension risk (all P values >0.3). We found no association between nitrites or nitrates and risks of cardiovascular diseases (all P values >0.2). Conclusions These results do not support a protective role of nitrites or nitrates in cardiovascular health. Instead, they suggest a positive association between nitrites from food additives and hypertension risk, which needs confirmation in other large-scale studies. These findings provide new evidence in the context of current discussions about updating regulations on the use of nitrites as food additives.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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