Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial
Parr EB, Kouw IWK, Wheeler MJ, Radford BE, Hall RC, Senden JM, Goessens JPB, van Loon LJC, Hawley JA
Obesity (Silver Spring, Md.) · 21 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- European Society for Clinical Nutrition and Metabolism
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-12-22 · Obesity (Silver Spring) · vol. 31 · issue S1 · pp. 116–126
- Publisher
- Wiley
- Cited
- 27 citations · more than 92% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 33 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Dietary Effects on Health · Muscle metabolism and nutrition · Circadian rhythm and melatonin
- Keywords
- Medicine, Overweight, Animal science, Internal medicine, Lean body mass, Body mass index, Obesity, Endocrinology, Randomized controlled trial, Body weight, Biology
- MeSH
- muscle, skeletal, humans, obesity, blood glucose, blood glucose self-monitoring, diet, adult, middle aged, male
9 authors
From AU, NL
- Evelyn B. Parr · correspondingAustralian Catholic University
- Imre W. K. KouwAustralian Catholic University
- Michael J. WheelerAustralian Catholic University
- Bridget E. RadfordAustralian Catholic University
- Rebecca C. HallAustralian Catholic University
- Joan M. SendenMaastricht University Medical Centre; Maastricht University
Abstract
Objective
This study aimed to assess the impact of time-restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity.
Methods
A total of 18 healthy males (age 46 ± 5 years; BMI: 30 ± 2 kg/m2 ) completed this exploratory, parallel, randomized dietary intervention after a 3-day lead-in diet. Participants then consumed an isoenergetic diet (protein: ~1.0 g/kg body mass per day) following either TRE (10:00 a.m. to 6:00 p.m.) or an extended eating control (CON; 8:00 a.m. to 8:00 p.m.) protocol for 10 days. Integrated MyoPS rates were measured using deuterated water administration with repeated saliva, blood, and muscle sampling. Secondary measures included continuous glucose monitoring and body composition (dual-energy x-ray absorptiometry).
Results
There were no differences in daily integrated MyoPS rates (TRE: 1.28% ± 0.18% per day, CON: 1.26% ± 0.22% per day; p = 0.82) between groups. From continuous glucose monitoring, 24-hour total area under the curve was reduced following TRE (-578 ± 271 vs. CON: 12 ± 272 mmol/L × 24 hours; p = 0.001). Total body mass declined (TRE: -1.6 ± 0.9 and CON: -1.1 ± 0.7 kg; p < 0.001) with no differences between groups (p = 0.22). Lean mass loss was greater following TRE compared with CON (-1.0 ± 0.7 vs. -0.2 ± 0.5 kg, respectively; p = 0.01).
Conclusion
Consuming food within an 8-hour time-restricted period does not lower daily MyoPS rates when compared with an isoenergetic diet consumed over 12 hours. Future research should investigate whether these results translate to free-living TRE.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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