Association of dietary magnesium intake and glycohemoglobin with mortality risk in diabetic patients
Wang HW, Huang YT, Jiang MY
PloS one · 6 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Chi Mei Medical Center
- Grants
- Chi Mei Medical Center (CMFHR11129)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2022-12-28 · PLoS One · vol. 17 · issue 12 · p. e0277180
- Publisher
- Public Library of Science
- Cited
- 11 citations · more than 72% of similar papers · 1.0× the field average
- References
- 32 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Keywords
- Medicine, Interquartile range, Diabetes mellitus, National Health and Nutrition Examination Survey, Population, Internal medicine, Cause of death, Endocrinology, Environmental health, Disease
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, magnesium, diet, nutrition surveys, risk factors, prospective studies, adult, middle aged, female, male, glycated hemoglobin
3 authors
From TW
- Hung‐Wei WangChi Mei Medical Center
- Yun‐Ting HuangChi Mei Medical Center
- Ming‐Yan Jiang · correspondingChi Mei Medical Center; Chia Nan University of Pharmacy and Science
Abstract
Background
Dietary magnesium intake inversely correlated to risk of death in general population. However, it is relatively unknown whether the beneficial effect remains significant in individuals with diabetes. Our study purpose is to evaluate the association of dietary magnesium intake with mortality risk in diabetic population.
Methods
The study population is recruited from 2003-2014 National Health and Nutrition Examination Survey, totaling 2,045 adults with diabetes being included. Participants were divided based on glycohemoglobin (HbA1c 250mg/day) ascertained by 24-hour dietary recall interviews.
Results
The average age of the study population was 52.9±10.1 years, with 49.1% being male. During a median follow-up of 77.0 months (interquartile range: 45.0-107.0 months), a total of 223 participants died (1.5 per 1000 person-months). Our results showed that individuals with lower dietary magnesium intake (≤250mg/day) had higher risk of all-cause (HR: 1.56, 95% CI: 1.13-2.16) and other-cause (non-cardiovascular and non-cancer) mortality (HR: 1.68, 95% CI: 1.09-2.60), while cardiovascular and cancer-related mortality were similar compared with individuals with magnesium intake > 250mg/day. We also showed that the risk of all-cause (HR: 1.86, 95% CI: 1.33-2.60) and other-cause mortality (HR: 2.03, 95% CI: 1.29-3.19) were higher in individuals with poorly controlled diabetes (HbA1c ≥7.0%) compared with HbA1c 250mg/day). When combining HbA1c and dietary magnesium intake, we showed that individuals with HbA1c ≥ 7% and dietary magnesium intake ≤ 250 mg/day had higher all-cause and other-cause (non-cardiovascular and non-cancer) mortality risk compared with those with HbA1c 250 mg/day.
Conclusion
Higher magnesium intake may help reduce mortality risk in individuals with diabetes and attenuate mortality risk of poor diabetic control.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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