Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals
Deota S, Lin T, Chaix A, Williams A, Le H, Calligaro H, Ramasamy R, Huang L, Panda S
Cell metabolism · 102 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Compton Foundation
- Nonprofit
- Mary K. Chapman Foundation
- Nonprofit
- Leona M. and Harry B. Helmsley Charitable Trust
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Cancer Institute
- Government
- National Institute of General Medical Sciences
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NCI NIH HHS
- Nonprofit
- Mary K Chapman Foundation
- Government
- NIDDK NIH HHS
- Government
- NIA NIH HHS
- Government
- NIGMS NIH HHS
- Grants
- National Cancer Institute (CA258221); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK115214); National Institute on Aging (R01 AG065993); National Cancer Institute (CA236352); National Institute of General Medical Sciences (T32-GM133351); National Institutes of Health (P30 014195); National Cancer Institute (P30014195); National Cancer Institute (R01 CA236352); National Cancer Institute (P30 CA-014195); National Cancer Institute (R01 CA258221); National Institutes of Health (CA258221); National Institutes of Health (DK115214); National Institutes of Health (CA236352); National Institutes of Health (AG065993)
Based on 13 listed funder(s).
Publication
- Published
- 2023-01-01 · Cell Metab · vol. 35 · issue 1 · pp. 150–165.e4
- Publisher
- Cell Press
- Cited
- 131 citations · more than 100% of similar papers · 18.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 80 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Keywords
- Transcriptome, Biology, Computational biology, Circadian rhythm, Cell biology, Neuroscience, Genetics, Gene, Gene expression
- MeSH
- animals, mammals, humans, mice, fasting, circadian rhythm, transcriptome, intermittent fasting
9 authors
From US
- Shaunak DeotaSalk Institute for Biological Studies
- Terry C. LinSalk Institute for Biological Studies
- Amandine ChaixSalk Institute for Biological Studies
- April E. WilliamsSalk Institute for Biological Studies
- Hiep D. LeSalk Institute for Biological Studies
- Hugo CalligaroSalk Institute for Biological Studies
Abstract
Time-restricted feeding (TRF) is an emerging behavioral nutrition intervention that involves a daily cycle of feeding and fasting. In both animals and humans, TRF has pleiotropic health benefits that arise from multiple organ systems, yet the molecular basis of TRF-mediated benefits is not well understood. Here, we subjected mice to isocaloric ad libitum feeding (ALF) or TRF of a western diet and examined gene expression changes in samples taken from 22 organs and brain regions collected every 2 h over a 24-h period. We discovered that TRF profoundly impacts gene expression. Nearly 80% of all genes show differential expression or rhythmicity under TRF in at least one tissue. Functional annotation of these changes revealed tissue- and pathway-specific impacts of TRF. These findings and resources provide a critical foundation for future mechanistic studies and will help to guide human time-restricted eating (TRE) interventions to treat various disease conditions with or without pharmacotherapies.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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