Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo-controlled clinical trial
Gholizadeh-Moghaddam M, Ghasemi-Tehrani H, Askari G, Jaripur M, Clark CCT, Rouhani MH
Health science reports · 11 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2022-12-29 · Health Sci Rep · vol. 6 · issue 1 · p. e1013
- Publisher
- Wiley
- Cited
- 15 citations · more than 80% of similar papers · 1.4× the field average
- References
- 34 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Ovarian function and disorders · Preterm Birth and Chorioamnionitis
- Keywords
- Polycystic ovary, Hyperandrogenism, hirsutism, Medicine, Randomized controlled trial, Placebo, Internal medicine, Endocrinology, Diabetes mellitus, Insulin resistance
6 authors
From IR, GB
- Mahsa Gholizadeh‐MoghaddamIsfahan University of Medical Sciences
- Hatav Ghasemi TehraniIsfahan University of Medical Sciences
- Gholamreza AskariIsfahan University of Medical Sciences
- Mahsima JaripurIsfahan University of Medical Sciences
- Cain C. T. ClarkCoventry University
- Mohammad Hossein Rouhani · correspondingIsfahan University of Medical Sciences
Abstract
Background and aims
Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women, which causes numerous symptoms in women. The relationship of many micronutrients with this syndrome has been investigated. This study was conducted to examine the effects of magnesium supplementation on hyperandrogenism, hirsutism, and sleep quality in women with PCOS.
Methods
In this parallel randomized clinical trial, 64 women with PCOS were randomly assigned to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. Patients in the magnesium group received one 250 mg magnesium oxide tablet, per day. Hyperandrogenism, hirsutism, and sleep quality were measured at the beginning and end of the study. This randomized clinical trial was registered at https://www.IRCT.ir (IRCT20130903014551N8).
Results
Magnesium supplementation had no significant effect on hyperandrogenism (p = 0.51 for dehydroepiandrosterone sulfates, p = 0.27 for testosterone), hirsutism (p = 0.23), and sleep quality (p = 0.85) compared with placebo.
Conclusions
The present study showed that a single dose of magnesium supplementation elicited no beneficial effects on the mentioned symptoms in polycystic women. It is possible that the positive effects of magnesium observed in the former studies were due to the synergistic effects of other vitamins or minerals. More studies are needed in this area.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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