Whole-body cryotherapy enhances the expression of heat shock protein 70 and related hormones
Eda N, Shimizu K, Takemura A, Narumi E, Nakamura M, Hoshikawa M, Dohi M
Cryo letters · 1 citation
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2022-03-01 · Cryo Letters · vol. 43 · issue 2 · pp. 83–90
- Publisher
- Cryo-Letters
- Cited
- 2 citations · more than 50% of similar papers · 0.2× the field average
- References
- 9 works
- Access
- Paywalled
- Research areas
- Exercise and Physiological Responses · Heat shock proteins research · Effects of Radiation Exposure
- Keywords
- Hematocrit, Hsp70, Medicine, Endocrinology, Lactate dehydrogenase, Internal medicine, Hormone, Adrenocorticotropic hormone, Venous blood, Hyperthermia, Heat shock protein, Chemistry
- MeSH
- humans, norepinephrine, cryopreservation, cryotherapy, adult, male, adrenocorticotropic hormone
7 authors
From JP
- Nobuhiko EdaDokkyo Medical University
- Kazuhiro ShimizuJapan Sport Council
- Ai TakemuraJapan Sport Council
- Emi NarumiJapan Sport Council
- Mariko NakamuraJapan Sport Council
- Masako HoshikawaJapan Sport Council
Abstract
Background
Whole-body cryotherapy (WBC) is used as a conditioning method for athletes. However, the scientific evidence for its effects is still insufficient.
Objective
To elucidate the effects of transient WBC on the expression of heat shock protein (HSP) 70 and the secretion of related hormones in humans.
Materials and methods
The participants in this study were six healthy adult men. WBC was performed for 3 min in a booth at a temperature in the range of -150 to -120 degree C, and measurements were taken immediately before (Pre), immediately after (Post), and 60 min after WBC (Post60). For measurement of core body temperature (gastrointestinal temperature), participants ingested a capsule-type wireless temperature sensor. The body surface temperature was measured using a noncontact thermometer, and measurements were taken at four sites on the body surface (chest, abdomen, front of the thigh, and front of the lower thigh). Leukocyte count, lactate dehydrogenase, creatine kinase, hemoglobin, hematocrit, adrenaline, noradrenaline, cortisol, adrenocorticotropic hormone (ACTH), erythropoietin, and HSP70 in the collected blood were measured.
Results
The results showed a decrease in body surface temperature and an increase in noradrenaline and ACTH immediately after WBC. In addition, the core body temperature decreased 60 min after WBC, accompanied by an increase in HSP70 expression.
Conclusion
WBC may increase HSP70 expression via noradrenaline and ACTH. The results of this study suggest the usefulness of WBC in triggering protein synthesis and the maintenance of immune function after training. doi.org/10.54680/fr22210110512.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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