Nitrate containing vegetables and dietary nitrate and nonalcoholic fatty liver disease: a case control study
Mirmiran P, Teymoori F, Farhadnejad H, Mokhtari E, Salehi-Sahlabadi A
Nutrition journal · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- Shahid Beheshti University of Medical Sciences
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-01-10 · Nutr J · vol. 22 · issue 1 · p. 3
- Publisher
- BioMed Central
- Cited
- 20 citations · more than 95% of similar papers · 4.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 31 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Nitric Oxide and Endothelin Effects · Liver Disease Diagnosis and Treatment
- Keywords
- Medicine, Nonalcoholic fatty liver disease, Nitrate, Odds ratio, Clinical nutrition, Internal medicine, Odds, Animal science, Fatty liver, Food science, Disease, Logistic regression, Biology
- MeSH
- humans, vegetables, nitrates, diet, risk factors, case-control studies, adult, iran, non-alcoholic fatty liver disease
5 authors
From IR
- Parvin MirmiranResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Farshad Teymoori · correspondingIran University of Medical Sciences; Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences; Tehran University of Medical Sciences
- Hossein Farhadnejad · correspondingResearch Institute for Endocrine Sciences; National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Ebrahim MokhtariResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Ammar Salehi‐SahlabadiNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
Abstract
Background
Vegetables is the main sources of dietary nitrate. Studies suggested the potential link between nitrate content of vegetables and reduce the risk of chronic diseases. We aimed to assess the association between nitrate-containing vegetables (NCVs) with odds of nonalcoholic fatty liver diseases (NAFLD) in Iranian adults.
Method
This case-control study was performed on a total of 225 newly diagnosed NAFLD cases and 450 controls aged 20-60 years. Individuals' dietary intakes were determined using a valid and reliable food frequency questionnaire.
Results
The mean ± SD age and BMI of participants were 38.1 ± 8.8 years and 26.8 ± 4.3 kg/m2, respectively. In the fully adjusted model, the odds of NAFLD were decreased across tertiles of total NCVs [(adjusted OR: 0.20, 95%CI: 0.10-0.40), (Ptrend trend < 0.001)]. Our results showed that each one SD increments in nitrate content of vegetables (adjusted OR: 0.73, 95%CI: 0.55-0.97) and nitrate content of fruits (adjusted OR: 0.59, 95%CI: 0.36-0.97) was associated with reduced odds of NAFLD (P < 0.05). However, there was a positive association between each one SD increments in nitrate content of dairy products and meats and processed meats with odds of NAFLD (adjusted OR: 1.34, 95%CI: 1.03-1.74), (P < 0.05).
Conclusion
Our finding suggested that a higher intake of vegetable nitrate may be related to a decrease the odds of NAFLD.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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