Implementation of weekday time-restricted eating to improve metabolic health in breast cancer survivors with overweight/obesity
Kirkham AA, Ford KL, Ramos Da Silva B, Topolnyski J, Prado CM, Joy AA, Paterson DI, Boulé N, Pituskin E, Haykowsky MJ, Thompson RB
Obesity (Silver Spring, Md.) · 21 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Heart and Stroke Foundation of Canada
- University or hospital
- University of Alberta
- Government
- Canadian Institutes of Health Research
Based on 3 listed funder(s).
Publication
- Published
- 2023-01-25 · Obesity (Silver Spring) · vol. 31 · issue S1 · pp. 150–160
- Publisher
- Wiley
- Cited
- 22 citations · more than 92% of similar papers · 3.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 30 works
- Access
- Free to read
- Research areas
- Dietary Effects on Health · Nutrition and Health in Aging · Cancer survivorship and care
- Keywords
- Overweight, Medicine, Obesity, Breast cancer, Oncology, Internal medicine, Gerontology, Environmental health, Cancer
- MeSH
- humans, breast neoplasms, obesity, exercise, aged, female, overweight, cancer survivors
11 authors
From CA
- Amy Ashley Kirkham · correspondingUniversity of Toronto
- Katherine L. FordUniversity of Alberta
- Bruna Ramos da SilvaUniversity of Alberta
- Jordan TopolnyskiUniversity of Alberta
- Carla Marques Maia PradoUniversity of Alberta
- Anil Abraham JoyUniversity of Alberta
Abstract
Objective
This study aimed to evaluate the implementation of telephone-based delivery of weekday-only time-restricted eating (TRE), its preliminary efficacy for metabolic outcomes, and concurrent lifestyle changes.
Methods
Twenty-two breast cancer survivors aged 60+ years with overweight/obesity completed an 8-week feasibility study of 12 to 8 p.m. weekday-only ad libitum TRE. The intervention was delivered by one registered dietitian call, twice-daily automated text messages asking about eating start and stop times, and three support phone calls. Magnetic resonance imaging, venipuncture, and 3 days of diet records and accelerometry were performed at baseline and after intervention.
Results
Participants had a mean age of 66 (SD 5) years with BMI of 31.8 (4.8) kg/m2 . Intervention implementation was successful, including excellent adherence (98%), participant acceptability, and a low symptom profile and cost ($63/participant). There were no significant changes in individual components of metabolic syndrome, lipid profile, or hemoglobin A1c , despite clinically relevant changes occurring within individual participants. Magnetic resonance imaging-derived hepatic steatosis and thigh myosteatosis did not change. Dietary intake changes included reduced energy (-22%) and protein (-0.2 g/kg). Physical activity and sleep did not change.
Conclusions
Eight weeks of telephone-delivered weekday TRE is a feasible, acceptable, low-symptom, and low-cost intervention. Future studies may consider a longer intervention length for more consistent metabolic improvements and counseling to enhance protein intake.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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