The Effect of Early Time-Restricted Eating vs Later Time-Restricted Eating on Weight Loss and Metabolic Health
Liu J, Yi P, Liu F
The Journal of clinical endocrinology and metabolism · 63 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National Key Research and Development Program of China
- Grants
- National Key Research and Development Program of China (2019YFA0801900); National Natural Science Foundation of China (81730022); National Key Research and Development Program of China (2018YFC2000100)
Based on 2 listed funder(s).
Publication
- Published
- 2023-01-26 · J Clin Endocrinol Metab · vol. 108 · issue 7 · pp. 1824–1834
- Publisher
- Oxford University Press
- Cited
- 90 citations · more than 99% of similar papers · 12.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 47 works
- Access
- Paywalled
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Enhanced Recovery After Surgery
- Keywords
- Overweight, Medicine, Glycemic, Weight loss, Insulin resistance, Context (archaeology), Cochrane Library, Randomized controlled trial, Internal medicine, Obesity, Blood pressure, Endocrinology, Eating behavior, Glucose homeostasis, Insulin, Biology
- MeSH
- humans, insulin resistance, obesity, body weight, weight loss, lipids, fasting, blood pressure, eating, adult, overweight
3 authors
From CN
- Juanhong LiuCentral South University; Second Xiangya Hospital of Central South University
- Yi PanGuangzhou Automobile Group (China)
- Feng Liu · correspondingCentral South University; Second Xiangya Hospital of Central South University
Abstract
Context
It remains controversial whether the choice of the daily eating window early or later in time-restricted eating (TRE) intervention (early or later TRE) has different effects on weight loss and metabolic health.
Objective
A network meta-analysis was performed to evaluate the efficacy between early and later TRE in adults with obesity or overweight.
Methods
We searched PubMed, Embase, Web of Science, and Cochrane Library for randomized controlled trials (RCTs) published until October 16, 2022. We conducted a network meta-analysis to evaluate the efficacy of early and later TRE on body weight and metabolic parameters, including glycemic metabolism, blood pressure, and lipid profiles.
Results
Twelve RCTs with 730 obese or overweight adults were included in this meta-analysis. Early TRE and later TRE both elicited moderate reductions in body weight and insulin resistance (IR) (homeostasis model assessment of IR) when compared to non-TRE. Interestingly, early TRE showed more effectiveness than later TRE in improving IR (early vs later TRE: -0.44; 95% CI, -0.86 to -0.02; P .05). In addition, early TRE rather than later TRE showed significant benefits in glycemic metabolism and blood pressure when compared to non-TRE. No significant differences between early and later TRE were observed for fasting blood glucose, blood pressure, and lipid profiles.
Conclusion
This meta-analysis suggests that people may choose early TRE for more effective weight management and metabolic benefits. Nevertheless, further large-scale RCTs are warranted to verify our findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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