Physiological and performance effects of dietary nitrate and N-acetylcysteine supplementation during prolonged heavy-intensity cycling
Tan R, Black M, Home J, Blackwell J, Clark I, Wylie L, Vanhatalo A, Jones AM
Journal of sports sciences · 4 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Unclassified
- no external funding
Based on 1 listed funder(s).
Publication
- Published
- 2022-12-02 · J Sports Sci · vol. 40 · issue 23 · pp. 2585–2594
- Publisher
- Taylor & Francis
- Cited
- 14 citations · more than 82% of similar papers · 1.3× the field average
- References
- 43 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Exercise and Physiological Responses · Cardiovascular and exercise physiology · Muscle metabolism and nutrition
- Keywords
- Cycling, Nitrite, Acetylcysteine, Animal science, Ingestion, Chemistry, Dietary Nitrate, Internal medicine, Nitrate, Endocrinology, Medicine, Food science, Antioxidant, Biochemistry, Biology
- MeSH
- humans, plant roots, nitrates, nitrites, reactive oxygen species, acetylcysteine, plant extracts, antioxidants, exercise, cross-over studies, oxygen consumption, dietary supplements, adult, male, fruit and vegetable juices, endurance training
8 authors
From GB
- Rachel TanUniversity of Exeter
- Matthew I. BlackUniversity of Exeter
- Joseph HomeUniversity of Exeter
- Jamie R. BlackwellUniversity of Exeter
- Ida E. ClarkUniversity of Exeter
- Lee J. WylieUniversity of Exeter
Abstract
The purpose of this study was to investigate effects of concurrent and independent administration of dietary nitrate (NO3-), administered as NO3--rich beetroot juice (BR; ~12.4 mmol of NO3-), and N-acetylcysteine (NAC; 70 mg·kg-1) on physiological responses during prolonged exercise and subsequent high-intensity exercise tolerance. Sixteen recreationally active males supplemented with NO3--depleted beetroot juice (PL) or BR for 6 days and ingested an acute dose of NAC or maltodextrin (MAL) 1 h prior to performing 1 h of heavy-intensity cycling exercise immediately followed by a severe-intensity time-to-exhaustion (TTE) test in four conditions: 1) PL+MAL, 2) PL+NAC, 3) BR+MAL and 4) BR+NAC. Pre-exercise plasma [NO3-] and nitrite ([NO2-]) were elevated following BR+NAC and BR+MAL (both P P P P < 0.05). There was no effect of supplementation on subsequent TTE . These findings indicate that co-ingestion of BR and NAC does not appreciably alter physiological responses during prolonged heavy-intensity cycling or enhance subsequent exercise tolerance.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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