Axial Shortening in Myopic Children after Repeated Low-Level Red-Light Therapy: Post Hoc Analysis of a Randomized Trial
Wang W, Jiang Y, Zhu Z, Zhang S, Xuan M, Tan X, Kong X, Zhong H, Bulloch G, Xiong R, Yuan Y, Chen Y, Zhang J, Zeng J, Morgan IG, He M
Ophthalmology and therapy · 57 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Fundamental Research Funds of the State key Laboratory of Ophthalmology
- Authors
- At least one author declares a financial tie to industry
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-02-15 · Ophthalmol Ther · vol. 12 · issue 2 · pp. 1223–1237
- Publisher
- Adis, Springer Healthcare
- Cited
- 66 citations · more than 99% of similar papers · 10.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Corneal surgery and disorders
- Keywords
- Medicine, Randomized controlled trial, Post-hoc analysis, Ophthalmology, Nuclear medicine, Surgery, Internal medicine
16 authors
From CN, AU
- Wei WangSun Yat-sen University
- Yu JiangSun Yat-sen University
- Zhuoting ZhuSun Yat-sen University; The University of Melbourne; Centre for Eye Research Australia
- Shiran ZhangSun Yat-sen University
- Meng XuanSun Yat-sen University
- Xingping TanCentral South University; Xiangya Hospital Central South University
Abstract
Introduction
Axial length (AL) elongation in myopia is considered irreversible. We aimed to systemically report unexpected AL shortening observed in a randomized clinical trial (RCT) after repeated low-level red-light (RLRL) therapy.
Methods
This is a post hoc analysis of a multicenter, single-masked RCT. Two hundred sixty-four myopic children aged 8-13 years allocated to RLRL treatment (intervention group) or a single vision spectacle (SVS, control group) were included. AL was measured using an IOL-master 500 at baseline, 1-, 3-, 6-, and 12-month follow-up visits. AL shortening was defined as AL reduction from baseline to follow-up visits at three cutoffs: > 0.05 mm, > 0.10 mm, and > 0.20 mm. Frequency of AL shortening at different cutoffs was calculated. Analysis was done with intent to treat (ITT).
Results
At 12-months follow up, frequency of AL shortening > 0.05 mm was 26/119 (21.85%) and 2/145 (1.38%) for the RLRL group versus the control group, respectively. The frequency was 18/119 (15.13%) versus 0/145 (0%) for AL shortening > 0.10 mm, and 7/119 (5.88%) versus 0/145 (0%), for AL shortening > 0.20 mm, respectively (p < 0.001). Mean AL shortening after 12 months (SD) was -0.156 (0.086) mm in the RLRL group and -0.06 mm in the control group. Age was significantly associated with AL shortening in the multivariable analysis. For the RLRL group that exhibited AL shortening (n = 56), choroidal thickness (ChT) thickening (0.056 mm) could only explain 28.3% of AL shortening (-0.20 mm).
Conclusion
Nearly a quarter of children had > 0.05 mm AL shortening following 12 months of RLRL therapy, whereas AL shortening rarely occurred among controls.
Trial registration
ClinicalTrials.gov (NCT04073238).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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