Adequate dietary magnesium intake may protect females but not males older than 55 years from cognitive impairment
Gao X, Sun Y, Huang X, Zhou Y, Zhu H, Li Q, Ma Y
Nutritional neuroscience · 4 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Unclassified
- [Community Cohort Study on Specialized Nervous System Diseases ]
Based on 1 listed funder(s).
Publication
- Published
- 2023-02-19 · Nutr Neurosci · vol. 27 · issue 2 · pp. 184–195
- Publisher
- Taylor & Francis
- Cited
- 3 citations · more than 54% of similar papers · 0.4× the field average
- References
- 38 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Trace Elements in Health
- Keywords
- Medicine, Logistic regression, Cognition, Cohort, Risk factor, Magnesium, Cognitive decline, Cohort study, Gerontology, Physiology, Internal medicine, Demography, Dementia, Disease, Psychiatry
- MeSH
- humans, magnesium, diet, cohort studies, cognition, aged, middle aged, female, male, cognitive dysfunction
7 authors
From CN
- Xian GaoHebei Medical University; First Affiliated Hospital of Hebei Medical University
- Yan SunHebei Medical University
- Xin HuangHebei Medical University; Handan College
- Yutian ZhouHebei Medical University
- Huichen ZhuHebei Medical University
- Qingxia LiHebei Medical University
Abstract
Background
Magnesium is an essential nutrient required to maintain brain health throughout life, and adequate magnesium intake is positively associated with cognitive performance in older adults. However, sex differences in magnesium metabolism have not been adequately assessed in humans.
Objectives
We investigated sex differences in the effect of dietary magnesium intake and the risk of different types of cognitive impairment in older Chinese adults.
Methods
We collected and assessed dietary data and cognitive function status in people aged 55 years and older in northern China who participated in the Community Cohort Study of Nervous System Diseases from 2018 to 2019 to explore the relationship between dietary magnesium intake and the risk of each type of mild cognitive impairment (MCI) in sex-specific cohorts of older adults.
Results
The study included 612 people: 260 (42.5%) men and 352 (57.5%) women. Logistic regression results showed that for the total sample and women's sample, high dietary magnesium intake reduced the risk of amnestic MCI (ORtotal = 0.300; ORwomen = 0.190) and multidomain amnestic MCI (ORtotal = 0.225; ORwomen = 0.145). The results of restricted cubic spline analysis showed that the risk of amnestic MCI (ptotal = 0.0193; pwomen = 0.0351) and multidomain amnestic MCI (ptotal = 0.0089; pwomen = 0.0096) in the total sample and women's sample gradually decreased with increasing dietary magnesium intake.
Conclusions
The results suggest that adequate magnesium intake may have a preventive effect against the risk of MCI in older women.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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