Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults
Nitescu M, Istratescu D, Preda CM, Manuc TE, Louis E, Manuc M, Stroie T, Catrinoiu M, Tieranu CG, Badea LE, Tugui L, Andrei A, Diculescu MM
Medicina (Kaunas, Lithuania) · 14 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2023-02-09 · Medicina (Kaunas) · vol. 59 · issue 2 · p. 329
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 17 citations · more than 93% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 61 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Digestive system and related health · Inflammatory Bowel Disease · Gastrointestinal motility and disorders
- Keywords
- Food science, Inflammatory Bowel Diseases, Medicine, Chemistry, Gastroenterology, Internal medicine, Inflammatory bowel disease
- MeSH
- animals, colitis, ulcerative, inflammatory bowel diseases, crohn disease, disaccharides, meat
13 authors
From RO, BE
- Maria NițescuCarol Davila University of Medicine and Pharmacy; National Institute of Research and Development for Biological Sciences
- Doina Istrătescu · correspondingCarol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
- Carmen Monica PredaCarol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
- Teodora Ecaterina ManucCarol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
- Edouard J. LouisUniversity of Liège; Centre Hospitalier Universitaire de Liège
- Mircea MănucCarol Davila University of Medicine and Pharmacy; Institutul Clinic Fundeni
Abstract
Background and Objectives: Inflammatory bowel diseases are a main focus in current research, with diet being an emerging therapeutic line due to its links in both onset and progression. A Western-style diet high in processed foods, food additives, red meat, and animal fat has been linked to a higher risk of developing IBD. The aim of this study was to establish an association between an anti-inflammatory exclusion diet and maintenance of remission in IBD. Also, we assessed the efficacy and safety of this diet compared to a non-dietary group and the possible therapeutic effect of this diet in the maintenance of IBD remission. Materials and Methods: A total of 160 patients with IBD were screened for inclusion, but 21 did not met the inclusion criteria. Thus, 139 patients were assigned to either an exclusion diet or a regular diet according to their choice. Results: Clinical remission after six months was maintained in the exclusion diet arm (100%). In the control arm, four patients had clinically active disease (one patient with UC and three with CD), and 90 patients maintained the clinical remission state (95.7%) (p-value = 0.157). Regarding biochemical markers, ESR at baseline was higher in the exclusion diet arm: 29 (5-62) versus in the control arm 16 (4-48) (p-value = 0.019), but six months after, the groups were similar (p-value = 0.440). Conclusions: Patients who followed an exclusion diet maintained clinical remission more frequently. However, the threshold for statistical significance was not achieved. There was also a trend of improvement in inflammation tests in the intervention group.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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