Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials
Luo B, Mohammad WT, Jalil AT, Saleh MM, Al-Taee MM, Alshahrani MY, Alshahrani MY, Mohammed NM, Heydani A
Complementary therapies in medicine · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Deanship of Scientific Research, King Khalid University
- Grants
- Deanship of Scientific Research, King Khalid University (RGP.02/122/43)
Based on 1 listed funder(s).
Publication
- Published
- 2023-02-24 · Complement Ther Med · vol. 73 · p. 102935
- Publisher
- Elsevier BV
- Cited
- 12 citations · more than 60% of similar papers · 0.8× the field average
- References
- 68 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Bee Products Chemical Analysis
- Keywords
- Meta-analysis, Medicine, Malondialdehyde, Publication bias, Oxidative stress, Randomized controlled trial, Web of science, Internal medicine, Antioxidant, MEDLINE, Systematic review, Traditional medicine, Biochemistry
- MeSH
- humans, antioxidants, oxidative stress, dietary supplements, biomarkers, prunus dulcis
8 authors
From CN, JO, IQ, SA
- Bingfeng Luo · correspondingFirst Hospital of Lanzhou University; Lanzhou University
- Walid Theib MohammadAl-Hussein Bin Talal University
- Abduladheem Turki Jalil · correspondingAlsalam University College; Al-Mustaqbal University
- Marwan Mahmood SalehUniversity of Anbar; Iraqi University; Islamic University of Najaf
- Muataz Mohammed Al‐TaeeAl-Nisour University College
- Mohammad Yahya AlshahraniKing Khalid University
Abstract
Background and aims
Several randomized controlled trials (RCTs) have shown that almonds can improve oxidative stress indices, but the results are controversial. Therefore, the goal of this research was to carry out a systematic review and meta-analysis of all RCTs that evaluated the effect of almonds on selected oxidative stress indices.
Methods
A systematic search was conducted up to April 2022 on PubMed, Scopus, Web of Science, and Google Scholar. We have selected the studies that investigated the effects of almonds on malondialdehyde (MDA), and oxidized low-density lipoprotein (Ox-LDL) levels in adults. Data were pooled by using the random-effects model. The risk of bias in individual studies was assessed using the Cochrane Collaboration risk of bias tool.
Results
Seven RCTs involving 424 participants were analyzed. The results indicated that almond intake led to a significant decrease in MDA levels (WMD: - 6.63 nmol/ml; 95 % CI: - 8.72 to - 4.54; P < 0.001). However, no significant effect was observed on Ox-LDL (Hedges' g: - 0.12; 95 % CI: - 0.34 to 0.10; P = 0.28). Sensitivity analysis showed that overall estimates were not affected by the elimination of any study. We did not observe any evidence regarding publication bias.
Conclusion
The present meta-analysis suggests that almond intake can improve MDA levels and might play a beneficial role in the reinforcement of the antioxidant defense system and amelioration of oxidative stress in adults. There is a need for more studies with larger groups to better estimate this effect.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.