Funded in part by Danone Global Research & Innovation Center
Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study
Nishi SK, Babio N, Paz-Graniel I, Serra-Majem L, Vioque J, Fitó M, Corella D, Pintó X, Bueno-Cavanillas A, Tur JA, Diez-Ricote L, Martinez JA, Gómez-Martínez C, González-Botella A, Castañer O, Alvarez-Sala A, Montesdeoca-Mendoza C, Fanlo-Maresma M, Cano-Ibáñez N, Bouzas C, Daimiel L, Zulet MÁ, Sievenpiper JL, Rodriguez KL, Vázquez-Ruiz Z, Salas-Salvadó J
BMC medicine · 37 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- Ministerio de Ciencia, Innovación y Universidades
- University or hospital
- Universitat Rovira i Virgili
- University or hospital
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- University or hospital
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Government
- Canadian Institutes of Health Research
- Government
- Instituto de Salud Carlos III
- Government
- H2020 European Research Council
- Government
- European Research Council
- Government
- Consejería de Salud de la Junta de Andalucía
- Government
- Fondo de Investigación para la Salud
- Government
- Fondo de Investigación para la Salud (FIS)
- Nonprofit
- Recercaixa
- Government
- Consellería de Innovación, Ciencia y Sociedad Digital, Generalitat Valenciana, Fondo Social Europeo-FS
- Company
- Danone Global Research & Innovation Center
- Government
- Canadian Institutes of Health Research (CIHR)
- Government
- Juan de la Cierva-Incorporación
- Authors
- At least one author declares a financial tie to industry
- Grants
- Universitat Rovira i Virgili (2020PMF-PIPF-37); Canadian Institutes of Health Research (171207_1); H2020 European Research Council (Eat2beNICE/ H2020-SFS-2016-2;847879); Ministerio de Ciencia, Innovación y Universidades (FPU 17/01925)
Based on 16 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-03-07 · BMC Med · vol. 21 · issue 1 · p. 82
- Publisher
- BioMed Central
- Cited
- 48 citations · more than 98% of similar papers · 6.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 89 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Thermoregulation and physiological responses · Sodium Intake and Health · Electrolyte and hormonal disorders
- Keywords
- Medicine, Prospective cohort study, Overweight, Cohort, Population, Cohort study, Cognition, Obesity, Internal medicine, Environmental health, Psychiatry
- MeSH
- humans, obesity, prospective studies, cognition, drinking, aged, female, male, overweight, metabolic syndrome
26 authors
From CA, ES
- Stephanie K. Nishi · correspondingSt. Michael's Hospital; Instituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
- Nancy Babió · correspondingInstituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
- Indira Paz‐GranielInstituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Universitat Rovira i Virgili
- Lluís Serra‐MajemUniversidad de Las Palmas de Gran Canaria; Hospital Universitario Insular de Gran Canaria; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red
- Jesús VioquéUniversitat de Miguel Hernández d'Elx; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública; Instituto de investigación sanitaria y biomédica de Alicante
- Montserrat FitóInstituto de Salud Carlos III; Centro de Investigación Biomédica en Red
Abstract
Background
Water intake and hydration status have been suggested to impact cognition; however, longitudinal evidence is limited and often inconsistent. This study aimed to longitudinally assess the association between hydration status and water intake based on current recommendations, with changes in cognition in an older Spanish population at high cardiovascular disease risk.
Methods
A prospective analysis was conducted of a cohort of 1957 adults (aged 55-75) with overweight/obesity (BMI between ≥ 27 and 2) and metabolic syndrome from the PREDIMED-Plus study. Participants had completed bloodwork and validated, semiquantitative beverage and food frequency questionnaires at baseline, as well as an extensive neuropsychological battery of 8 validated tests at baseline and 2 years of follow-up. Hydration status was determined by serum osmolarity calculation and categorized as < 295 mmol/L (hydrated), 295-299.9 mmol/L (impending dehydration), and ≥ 300 mmol/L (dehydrated). Water intake was assessed as total drinking water intake and total water intake from food and beverages and according to EFSA recommendations. Global cognitive function was determined as a composite z-score summarizing individual participant results from all neuropsychological tests. Multivariable linear regression models were fitted to assess the associations between baseline hydration status and fluid intake, continuously and categorically, with 2-year changes in cognitive performance.
Results
The mean baseline daily total water intake was 2871 ± 676 mL/day (2889 ± 677 mL/day in men; 2854 ± 674 mL/day in women), and 80.2% of participants met the ESFA reference values for an adequate intake. Serum osmolarity (mean 298 ± 24 mmol/L, range 263 to 347 mmol/L) indicated that 56% of participants were physiologically dehydrated. Lower physiological hydration status (i.e., greater serum osmolarity) was associated with a greater decline in global cognitive function z-score over a 2-year period (β: - 0.010; 95% CI - 0.017 to - 0.004, p-value = 0.002). No significant associations were observed between water intake from beverages and/or foods with 2-year changes in global cognitive function.
Conclusions
Reduced physiological hydration status was associated with greater reductions in global cognitive function over a 2-year period in older adults with metabolic syndrome and overweight or obesity. Future research assessing the impact of hydration on cognitive performance over a longer duration is needed.
Trial registration
International Standard Randomized Controlled Trial Registry, ISRCTN89898870. Retrospectively registered on 24 July 2014.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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