Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
Alateeq K, Walsh EI, Cherbuin N
European journal of nutrition · 12 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Australian National University
Based on 1 listed funder(s).
Publication
- Published
- 2023-03-10 · Eur J Nutr · vol. 62 · issue 5 · pp. 2039–2051
- Publisher
- Springer Science+Business Media
- Cited
- 21 citations · more than 89% of similar papers · 2.6× the field average
- References
- 63 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Magnesium Alloys: Properties and Applications
- Keywords
- Medicine, White matter, Linear regression, Demography, Internal medicine, Physiology, Endocrinology, Magnetic resonance imaging
- MeSH
- brain, humans, magnesium, magnetic resonance imaging, sex characteristics, female, male, white matter
3 authors
From AU, SA
- Khawlah Alateeq · correspondingAustralian National University; King Saud Medical City; King Saud University
- Erin WalshAustralian National University
- Nicolas CherbuinAustralian National University
Abstract
Purpose
To examine the association between dietary magnesium (Mg) intake and brain volumes and white matter lesions (WMLs) in middle to early old age.
Methods
Participants (aged 40-73 years) from UK Biobank (n = 6001) were included and stratified by sex. Dietary Mg was measured using an online computerised 24 h recall questionnaire to estimate daily Mg intake. Latent class analysis and hierarchical linear regression models were performed to investigate the association between baseline dietary Mg, Mg trajectories, and brain volumes and WMLs. Associations between baseline Mg, and baseline blood pressure (BP) measures, and baseline Mg, Mg trajectories and BP changes (between baseline and wave 2) were also investigated to assess whether BP mediates the link between Mg intake and brain health. All analyses controlled for health and socio-demographic covariates. Possible interactions between menopausal status and Mg trajectories in predicting brain volumes and WMLs were also investigated.
Results
On average, higher baseline dietary Mg intake was associated with larger brain volumes (gray matter [GM]: 0.001% [SE = 0.0003]; left hippocampus [LHC]: 0.0013% [SE = 0.0006]; and right hippocampus [RHC]: 0.0023% [SE = 0.0006]) in both men and women. Latent class analysis of Mg intake revealed three classes: "high-decreasing" (men = 3.2%, women = 1.9%), "low-increasing" (men = 1.09%, women = 1.62%), and "stable normal" (men = 95.71%, women = 96.51%). In women, only the "high-decreasing" trajectory was significantly associated with larger brain volumes (GM: 1.17%, [SE = 0.58]; and RHC: 2.79% [SE = 1.11]) compared to the "normal-stable", the "low-increasing" trajectory was associated with smaller brain volumes (GM: - 1.67%, [SE = 0.30]; white matter [WM]: - 0.85% [SE = 0.42]; LHC: - 2.43% [SE = 0.59]; and RHC: - 1.50% [SE = 0.57]) and larger WMLs (1.6% [SE = 0.53]). Associations between Mg and BP measures were mostly non-significant. Furthermore, the observed neuroprotective effect of higher dietary Mg intake in the "high-decreasing" trajectory appears to be greater in post-menopausal than pre-menopausal women.
Conclusions
Higher dietary Mg intake is related to better brain health in the general population, and particularly in women.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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