Red Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass
Prudêncio APA, Fonseca DC, Machado NM, Alves JTM, Sala P, Fernandes GR, Torrinhas RS, Waitzberg DL
Nutrients · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Government
- Coordenação de Aperfeicoamento de Pessoal de Nível Superior
- Government
- FAPESP
- Government
- São Paulo Research Foundation
- Authors
- At least one author declares a financial tie to industry
- Grants
- Fundação de Amparo à Pesquisa do Estado de São Paulo (11/09612-3)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-02-27 · Nutrients · vol. 15 · issue 5 · p. 1185
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 19 citations · more than 90% of similar papers · 2.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Diet and metabolism studies · Nutritional Studies and Diet · Fatty Acid Research and Health
- Keywords
- Insulin resistance, Affect (linguistics), Insulin, Internal medicine, Endocrinology, Medicine, Food science, Chemistry, Psychology, Communication
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, obesity, morbid, acetates, indoles, insulin, blood glucose, tryptophan, rna, ribosomal, 16s, gastric bypass, female, red meat, eubacteriales
8 authors
From BR
- Ana Paula Aguiar PrudêncioHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Danielle Cristina FonsecaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Natasha Mendonça MachadoHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Juliana Tepedino Martins AlvesHospital Sírio-Libanês
- Priscila SalaCentro Universitário São Camilo
- Gabriel da Rocha FernandesFundação Oswaldo Cruz
Abstract
Roux-en-Y Gastric bypass (RYGB) promotes improvement in type 2 diabetes (T2D) shortly after surgery, with metabolic mechanisms yet to be elucidated. This study aimed to investigate the relationship between food intake, tryptophan metabolism, and gut microbiota on the glycemic control of obese T2D women after RYGB surgery. Twenty T2D women who underwent RYGB were evaluated before and three months after surgery. Food intake data were obtained by a seven-day food record and a food frequency questionnaire. Tryptophan metabolites were determined by untargeted metabolomic analysis, and the gut microbiota was determined by 16S rRNA sequencing. The glycemic outcomes were fasting blood glucose, HbA1C, HOMA-IR, and HOMA-beta. Linear regression models were applied to assess the associations between the changes in food intake, tryptophan metabolism, and gut microbiota on glycemic control after RYGB. All variables changed after RYGB (p Dorea longicatena was associated with postoperative HOMA-IR {R2 0.80, R2 adj 0.74; p Dorea longicatena increased in the same period. These combined variables were associated with better insulin resistance in T2D women after RYGB.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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