Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases: A systematic review and meta-analysis
Monteiro EB, Ajackson M, Stockler-Pinto MB, Guebre-Egziabher F, Daleprane JB, Soulage CO
Life sciences · 17 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Based on 1 listed funder(s).
Publication
- Published
- 2023-04-05 · Life Sci · vol. 322 · p. 121664
- Publisher
- Elsevier BV
- Cited
- 24 citations · more than 67% of similar papers · 0.7× the field average
- References
- 63 works
- Access
- Free to read
- Research areas
- Genomics, phytochemicals, and oxidative stress · Advanced Glycation End Products research · Sulfur Compounds in Biology
- Keywords
- Renal function, Medicine, Creatinine, Urology, Kidney disease, Sulforaphane, Kidney, Internal medicine, Acute kidney injury, Proteinuria, Glomerulosclerosis, Gastroenterology, Endocrinology, Pathology
- MeSH
- humans, kidney diseases, isothiocyanates, sulfoxides, creatinine, nf-e2-related factor 2, biomarkers, kelch-like ech-associated protein 1
6 authors
From BR, FR
- Elisa Bernardes MonteiroUniversidade do Estado do Rio de Janeiro
- Matheus AjacksonUniversidade do Estado do Rio de Janeiro
- Milena Barcza Stockler‐PintoUniversidade Federal Fluminense
- Fitsum Guebre‐EgziabherLyon 1 Université; Inserm; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Hospices Civils de Lyon; Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition
- Júlio Beltrame DalepraneUniversidade do Estado do Rio de Janeiro
- Christophe Olivier Soulage · correspondingLyon 1 Université; Inserm; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition
Abstract
Aims
Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, has received extensive attention as a natural activator of the Nrf2/Keap1 cytoprotective pathway. In this review, a meta-analysis and systematic review of the renoprotective effects of SFN were performed in various preclinical models of kidney diseases.
Main methods
The primary outcome was the impact of SFN on renal function biomarkers (uremia, creatininemia, proteinuria or creatinine clearance) and secondary outcomes were kidney lesion histological indices/kidney injury molecular biomarkers. The effects of SFN were evaluated according to the standardized mean differences (SMDs). A random-effects model was applied to estimate the overall summary effect.
Key findings
Twenty-five articles (out of 209 studies) were selected from the literature. SFN administration significantly increased creatinine clearance (SMD +1.88 95 % CI: [1.09; 2.68], P 2 = 0 %) and decreased the plasma creatinine (SMD -1.24, [-1.59; -0.88], P 2 = 36.0 %) and urea (SMD -3.22 [-4.42, -2.01], P 2 = 72.4 %) levels. SFN administration (median dose: 2.5 mg/kg, median duration: 3 weeks) significantly decreased urinary protein excretion (SMD -2.20 [-2.68; -1.73], P 2 = 34.1 %). It further improved two kidney lesion histological indices namely kidney fibrosis (SMD -3.08 [-4.53; -1.63], P 2 = 73.7 %) and glomerulosclerosis (SMD -2.24 [-2.96; -1.53], P 2 = 9.7 %) and decreased kidney injury molecular biomarkers (SMD -1.51 [-2.00; -1.02], P 2 = 0 %).
Significance
These findings provide new insights concerning preclinical strategies for treating kidney disease or kidney failure with SFN supplements and should stimulate interest in clinical evaluations of SFN in patients with kidney disease.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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