Intermittent fasting modulates the intestinal microbiota and improves obesity and host energy metabolism
Hu X, Xia K, Dai M, Han X, Yuan P, Liu J, Liu S, Jia F, Chen J, Jiang F, Yu J, Yang H, Wang J, Xu X, Jin X, Kristiansen K, Xiao L, Chen W, Han M, Duan S
NPJ biofilms and microbiomes · 56 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Xiangya Hospital, Central South University
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-04-07 · NPJ Biofilms Microbiomes · vol. 9 · issue 1 · p. 19
- Publisher
- Nature Portfolio
- Cited
- 62 citations · more than 99% of similar papers · 8.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 47 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Gut microbiota and health · Diet and metabolism studies
- Keywords
- Metagenomics, Bacteroides, Gut flora, Biology, Microbiome, Obesity, Feces, Body mass index, Shotgun sequencing, Physiology, Microbiology, Genetics, Endocrinology, Bacteria, Immunology, Genome, Gene
- MeSH
- humans, obesity, rna, ribosomal, 16s, metagenome, gastrointestinal microbiome, intermittent fasting
20 authors
From CN, DK
- Xiangwei HuBGI Group (China); Zhengzhou University
- Kai XiaChina National Research Institute of Food and Fermentation
- Minhui DaiCentral South University; Xiangya Hospital Central South University
- Xiao-Feng HanChina National Research Institute of Food and Fermentation
- Peng YuanChina National Research Institute of Food and Fermentation
- Jia LiuChina National Research Institute of Food and Fermentation
Abstract
Intermittent fasting (IF) is a promising paradigm for weight loss which has been shown to modulate the gut microbiota based on 16S rRNA gene amplicon sequencing. Here, 72 Chinese volunteers with a wide range of body mass index (BMI) participated in a three-week IF program during which an average loss of 3.67 kg body weight accompanied with improved clinical parameters was observed irrespective of initial anthropometric and gut microbiota status. Fecal samples were collected before and after the intervention and subjected to shotgun metagenomic sequencing. De novo assembly yielded 2934 metagenome-assembled genomes (MAGs). Profiling revealed significant enrichment of Parabacteroides distasonis and Bacteroides thetaiotaomicron after the intervention, with inverse correlations between their relative abundances and parameters related to obesity and atherosclerotic cardiovascular diseases (ASCVD). MAGs enriched after the intervention showed high richness and diversity of carbohydrate-active enzymes, with an increased relative abundances of genes related to succinate production and glutamate fermentation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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