Funded in part by New Capstone Inc
Relationship between short-term self-reported dietary magnesium intake and whole blood ionized magnesium (iMg2+) or serum magnesium (s-Mg) concentrations
Ansu Baidoo VY, Thiagarajah K, Tekwe CD, Wallace TC, Gletsu-Miller N
Annals of medicine · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Company
- New Capstone Inc
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK132385)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-04-10 · Ann Med · vol. 55 · issue 1 · p. 2195702
- Publisher
- Informa
- Cited
- 6 citations · more than 66% of similar papers · 0.7× the field average
- References
- 21 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Plant Micronutrient Interactions and Effects · Parathyroid Disorders and Treatments
- Keywords
- Magnesium, Hypomagnesemia, Bioavailability, Magnesium deficiency (plants), Animal science, Chemistry, Dietary Reference Intake, Medicine, Crossover study, Internal medicine, Whole blood, Endocrinology, Nutrient, Pharmacology, Biology
- MeSH
- humans, magnesium, nutritional status, adult, self report
5 authors
From US
- Velarie AnsuNorthwestern University
- Krisha ThiagarajahIndiana University Bloomington
- Carmen D. TekweIndiana University Bloomington
- Taylor C. WallaceGeorge Mason University
- Nana Gletsu‐Miller · correspondingIndiana University Bloomington
Abstract
Objective
Since we and others have shown that supplemental magnesium raises whole blood ionized magnesium (iMg2+) we investigated the relationships between self-reported dietary magnesium intake and concentrations of whole blood iMg2+ and serum magnesium (s-Mg).
Methods
We obtained whole blood iMg2+ concentrations, as well as s-Mg concentrations, from a pilot, three-arm, randomized, controlled, crossover bioavailability study of magnesium supplements (n = 23; 105 measures). Dietary magnesium intake was assessed using three-day food records and the Nutrition Data System for Research (NDSR, University of Minnesota, MN, USA). Whole blood iMg2+ was measured with an electrode analyser (NOVA Biochemical, Waltham, MA, USA), whereas s-Mg was measured using atomic absorption spectroscopy. A linear mixed-effects model was employed with dietary magnesium as the outcome variable and iMg2+, s-Mg, study treatment and study visit as fixed effects. We adjusted age, gender, race and body mass index covariates.
Results
Values for dietary magnesium, iMg2+ and s-Mg were 303.8 ± 118.9 mg/day, 1.3 ± 0.1 mg/dL and 2.2 ± 4.1 mg/dL, respectively. No association was found between dietary magnesium intake and iMg2+ -125 ± 176.95 (p = .49) or s-Mg -9.33 ± 5.04 (p = .08).
Conclusions
Whole blood iMg2+ and s-Mg concentrations do not reflect short-term self-reported dietary intake in adults. Further research is needed to determine whether blood biomarkers of magnesium may reflect dietary magnesium intake.Key messagesDietary intake of magnesium, a shortfall nutrient, may be objectively measured using blood biomarkers of magnesium.Serum magnesium and whole blood iMg2+ were not associated with short-term dietary intake of magnesium.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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