The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review
Berni M, Brancato AM, Torriani C, Bina V, Annunziata S, Cornella E, Trucchi M, Jannelli E, Mosconi M, Gastaldi G, Caliogna L, Grassi FA, Pasta G
International journal of molecular sciences · 77 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Unclassified
- Trattamenti innovativi per le patologie muscolo scheletriche: dal planning virtuale preoperatorio alla medicina rigenerativa TI-RAMS
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-04-12 · Int J Mol Sci · vol. 24 · issue 8 · p. 7094
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 102 citations · more than 99% of similar papers · 6.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Laser Applications in Dentistry and Medicine
- Keywords
- Low level laser therapy, Bone healing, Angiogenesis, Wound healing, Medicine, In vivo, Stem-cell therapy, Laser therapy, Stem cell, Orthopedic surgery, Bioinformatics, Dentistry, Laser, Cancer research, Pathology, Surgery, Mesenchymal stem cell, Cell biology, Biology, Biotechnology
- MeSH
- stem cells, fracture healing, cell differentiation, osteogenesis, low-level light therapy
13 authors
From IT
- Micaela BerniPoliclinico San Matteo Fondazione; Istituti di Ricovero e Cura a Carattere Scientifico
- Alice Maria Brancato · correspondingPoliclinico San Matteo Fondazione; Istituti di Ricovero e Cura a Carattere Scientifico
- Camilla TorrianiPoliclinico San Matteo Fondazione; Istituti di Ricovero e Cura a Carattere Scientifico
- Valentina BinaUniversity of Pavia
- Salvatore AnnunziataPoliclinico San Matteo Fondazione; Istituti di Ricovero e Cura a Carattere Scientifico
- Elena CornellaPoliclinico San Matteo Fondazione; Istituti di Ricovero e Cura a Carattere Scientifico
Abstract
Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process. A better understanding of the cellular mechanisms activated by LLLT can improve its clinical application.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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