PNPLA3 GENE POLYMORPHISM AND RED MEAT CONSUMPTION INCREASED FIBROSIS RISK IN NASH BIOPSY-PROVEN PATIENTS UNDER MEDICAL FOLLOW-UP IN A TERTIARY CENTER IN SOUTHWEST BRAZIL
Yoshimura SM, Duarte SMB, Stefano JT, Mazo DFC, Mazo DFC, Pinho JRR, Oliveira CP
Arquivos de gastroenterologia · 2 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Based on 1 listed funder(s).
Publication
- Published
- 2023-01-01 · Arq Gastroenterol · vol. 60 · issue 1 · pp. 98–105
- Publisher
- Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
- Cited
- 2 citations · more than 58% of similar papers · 0.3× the field average
- References
- 31 works
- Access
- Open access (free to publish) · CC-BY-NC
- Research areas
- Liver Disease Diagnosis and Treatment · Liver Diseases and Immunity · Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- Medicine, Odds ratio, Gastroenterology, Internal medicine, Single-nucleotide polymorphism, Red meat, Waist, Nonalcoholic fatty liver disease, Fatty liver, Steatohepatitis, Genotype, Gene polymorphism, Genotyping, Pathology, Body mass index, Gene, Genetics, Disease, Biology
- MeSH
- humans, liver cirrhosis, genetic predisposition to disease, acyltransferases, biopsy, follow-up studies, cross-sectional studies, polymorphism, single nucleotide, brazil, phospholipases a2, calcium-independent, non-alcoholic fatty liver disease, red meat
6 authors
From BR
- S. YoshimuraUniversidade de São Paulo; Universidade Brasil
- Sebastião Mauro Bezerra DuarteUniversidade de São Paulo; Universidade Brasil
- José Tadeu StefanoUniversidade de São Paulo; Universidade Brasil
- Daniel de Mello FerrazUniversidade de São Paulo; Universidade Brasil
- João Renato Rebello PinhoUniversidade de São Paulo; Universidade Brasil
- Claudia Pinto Marques Souza de OliveiraUniversidade de São Paulo
Abstract
Background
Recent studies show an increase in nonalcoholic fatty liver disease (NAFLD) in populations with higher consumption of red meat, processed and cooked at high temperatures. On the other hand, the single nucleotide polymorphism rs738409 in the Patatin-like phospholipase domain containing 3 (PNPLA3) gene has been implicated in susceptibility to NAFLD and liver fibrosis. However, the synergistic effect between red meat consumption and the PNPLA3 gene polymorphism in NAFLD has not yet been evaluated.
Objective
To evaluate the association between the presence of the polymorphism in the PNPLA3 gene and the consumption of macronutrients, including meat consumption and its cooking method among NAFLD patients.
Methods
This was a cross-sectional study with 91 patients diagnosed with NAFLD by liver biopsy with genotyping for the polymorphism in the PNPLA3 gene were included. The consumption of calories and macronutrients was verified using the semi-quantitative food frequency questionnaire and the specific questionnaire on meat consumption. PNPLA3 gene polymorphism was analyzed by real-time polymerase chain reaction (RT-PCR) and anthropometric evaluation was realized.
Results
The mean BMI was 32.38±4.58 kg/m² and the waist circumference was 107±10 cm. On liver biopsy, 42% of patients had significant fibrosis (F≥2). The odds ratio of F≥2 was 2.12 for the GG group and 1.54 for the CG group, compared to the CC group. The mean caloric intake was 1170±463.20 kcal/d. The odds ratio in the CC group concerning high red meat consumption in comparison to low consumption was 1.33. For white meat, the odds ratio was 0.8 when comparing high and low intake, also in the CC group.
Conclusion
High red meat intake and PNPLA3 gene polymorphism seem to synergistically affect NAFLD and liver fibrosis, requiring confirmation in a larger number of patients and in different populations.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.