The role of resistance training and creatine supplementation on oxidative stress, antioxidant defense, muscle strength, and quality of life in older adults
Amiri E, Sheikholeslami-Vatani D
Frontiers in public health · 35 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2023-05-02 · Front Public Health · vol. 11 · p. 1062832
- Publisher
- Frontiers Media
- Cited
- 48 citations · more than 96% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 40 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Exercise and Physiological Responses · Muscle metabolism and nutrition · Biochemical effects in animals
- Keywords
- Creatine Monohydrate, Malondialdehyde, Medicine, Creatine, Glutathione peroxidase, Placebo, Oxidative stress, Creatinine, Antioxidant, Internal medicine, Creatine kinase, Endocrinology, Physical therapy, Superoxide dismutase, Biochemistry, Chemistry, Pathology
- MeSH
- humans, creatine, antioxidants, oxidative stress, quality of life, dietary supplements, aged, female, male, muscle strength, resistance training
2 authors
From IR
- Ehsan AmiriUniversity of Kurdistan
- Dariush Sheikholeslami‐Vatani · correspondingUniversity of Kurdistan
Abstract
Background
The aim of this study was to evaluate the effect of resistance training (RT) with creatine monohydrate supplementation (CS) on serum levels of 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), glutathione peroxidase (GPX), and total antioxidant capacity (TAC) in older adults.
Objectives
This study evaluated the effect of resistance training with creatine monohydrate supplementation on oxidative stress and antioxidant defense, muscle strength and quality of life in older adults.
Methods
We examined 45 non-athlete volunteer older men and women (mean, 68.1 ± 7.2 years old), were randomly selected and divided into three groups of 15: RT with creatine supplementation (RT + CS), RT with placebo (RT + P) and control group. RT protocol was performed for 10 weeks, three sessions per week. Creatine supplement was taken daily at a dose of 0.1 g/kg of body weight, while the placebo group consumed the same amount of starch. Fasting blood samples were taken before the start of program and at the end of the RT period.
Results
In the training groups, after 10 weeks of RT, a significant decrease in MDA and 8 - OHDG as well as a significant increase in serum levels of GPX and TAC were observed (in all cases, p = 0.001). In addition, creatinine levels were enhanced in the RT + CS (p = 0.014). Training intervention also improved quality of life and muscle strength in the experimental groups (p = 0.001), although muscle strength changes were more visible in the RT + CS group than in the RT + P group (p < 0/05).
Conclusion
Regular resistance training can be recommended as a very suitable non-pharmacological approach to strengthen the body's antioxidant system, muscle strength and quality of life in older adults. There are no definite findings on the role of creatine on the antioxidant system and quality of life in older adults, but the use of this supplement in addition to RT can double the amount of strength gained from resistance training.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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