Maternal magnesium intake and childhood wheezing in offspring at 3 years of age: the Japan Environment and Children's Study
Murata T, Kyozuka H, Fukuda T, Imaizumi K, Isogami H, Yasuda S, Yamaguchi A, Sato A, Ogata Y, Shinoki K, Hosoya M, Yasumura S, Hashimoto K, Nishigori H, Fujimori K, Japan Environment and Children’s Study (JECS) Group
The British journal of nutrition · 0 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Center for Child Health and Development
- University or hospital
- University of Occupational and Environmental Health
- University or hospital
- Hyogo College of Medicine
- University or hospital
- Hokkaido University
- University or hospital
- Chiba University
- University or hospital
- Nagoya City University
Based on 6 listed funder(s).
Publication
- Published
- 2023-05-26 · Br J Nutr · vol. 130 · issue 11 · pp. 1973–1981
- Publisher
- Cambridge University Press
- Cited
- 2 citations · more than 78% of similar papers · 1.0× the field average
- References
- 37 works
- Access
- Free to read
- Research areas
- Birth, Development, and Health · Neonatal Respiratory Health Research · Pregnancy and preeclampsia studies
- Keywords
- Offspring, Medicine, Incidence (geometry), Pregnancy, Confounding, Logistic regression, Pediatrics, Demography, Internal medicine, Biology
- MeSH
- humans, prenatal exposure delayed effects, respiratory sounds, magnesium, diet, incidence, pregnancy, adult, child, preschool, japan, female, male, maternal nutritional physiological phenomena
16 authors
From JP
- Tsuyoshi Murata · correspondingFukushima Medical University; Fukushima Prefectural Culture Center
- Hyo KyozukaFukushima Medical University; Fukushima Prefectural Culture Center
- Toma FukudaFukushima Medical University; Fukushima Prefectural Culture Center
- Karin ImaizumiFukushima Medical University; Fukushima Prefectural Culture Center
- Hirotaka IsogamiFukushima Medical University; Fukushima Prefectural Culture Center
- Shun YasudaFukushima Medical University; Fukushima Prefectural Culture Center
Abstract
This study evaluated the association between maternal magnesium intake (MMI) and childhood wheezing incidence in 3-year-old offspring. We hypothesised that higher MMI imparts anti-inflammatory and antioxidant effects that decrease childhood wheezing incidence in offspring. Data of 79 907 women (singleton pregnancy, ≥ 22 weeks) from the Japan Environment and Children's Study (enrolled between 2011 and 2014) were analysed. Participants were categorised into quintiles of MMI (< 148·00, 148·00-187·99, 188·00-228·99, 229·00-289·99 and ≥ 290·00 mg/d), quintiles of adjusted MMI for daily energy intake (aMMI) (< 0·107, 0·107-0·119, 0·120-0·132, 0·133-0·149 and ≥ 0·150 mg/kcal) and MMI levels either below or above the ideal value (< 310·00 or ≥ 310·00 mg/d). Multivariable logistic regression analysis was performed to calculate OR for the incidence of childhood wheezing in offspring among participants in each MMI category, with the lowest MMI group considered the reference group. Maternal demographic, socio-economic, medical and other nutrient intake backgrounds were considered potential confounding factors. The adjusted OR (aOR) for childhood wheezing in the offspring of women with the highest MMI was 1·09 (95 % CI, 1·00, 1·20), whereas that calculated based on aMMI categories and offspring of women with above-ideal MMI levels remained unchanged. The highest MMI was associated with slightly increased childhood wheezing incidence in the offspring. MMI during pregnancy had an insignificant clinical impact on this incidence; moreover, modifying MMI would not significantly improve childhood wheezing incidence in offspring. Therefore, further studies should clarify the association between other prenatal factors and childhood wheezing incidence in offspring.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.