Funded in part by Novo Nordisk, Novo Nordisk Fonden
Time-restricted feeding attenuates hypercholesterolaemia and atherosclerosis development during circadian disturbance in APOE∗3-Leiden.CETP mice
In Het Panhuis W, Schönke M, Modder M, Tom HE, Lalai RA, Pronk ACM, Streefland TCM, van Kerkhof LWM, Dollé MET, Depuydt MAC, Bot I, Vos WG, Bosmans LA, van Os BW, Lutgens E, Rensen PCN, Kooijman S
EBioMedicine · 28 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- Ministerie van Sociale Zaken en Werkgelegenheid
- Government
- Deutsche Forschungsgemeinschaft
- Nonprofit
- Hartstichting
- Government
- Ministerie van Volksgezondheid, Welzijn en Sport
- University or hospital
- Academisch Medisch Centrum
- Government
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Company
- Novo Nordisk
- Company
- Novo Nordisk Fonden
- Government
- National Institutes of Health
- University or hospital
- Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers
- Government
- European Research Council
- Government
- Rijksinstituut voor Volksgezondheid en Milieu
- Government
- National Institute on Aging
- Government
- NIA NIH HHS
- Grants
- National Institute on Aging (P01- AG017242); Ministerie van Sociale Zaken en Werkgelegenheid (1292.19.077); Novo Nordisk Fonden (NNF18OC0032394); Deutsche Forschungsgemeinschaft (SFB1123); Ministerie van Volksgezondheid, Welzijn en Sport (AG-17242); Nederlandse Organisatie voor Wetenschappelijk Onderzoek (1292.19.077); Hartstichting (2017T016); Ministerie van Volksgezondheid, Welzijn en Sport (1292.19.077)
Based on 14 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-06-24 · EBioMedicine · vol. 93 · p. 104680
- Publisher
- Elsevier BV
- Cited
- 31 citations · more than 93% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 54 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Circadian rhythm and melatonin · Dietary Effects on Health · Sleep and Work-Related Fatigue
- Keywords
- Circadian rhythm, Internal medicine, Endocrinology, Cholesterol, Apolipoprotein E, Apolipoprotein B, Endogeny, Medicine, Biology, Disease
- MeSH
- animals, humans, mice, hypercholesterolemia, cholesterol, circadian rhythm, photoperiod, female, atherosclerosis, apolipoprotein e3, cholesterol ester transfer proteins
17 authors
From NL, US
- Wietse In het PanhuisLeiden University; University of Applied Sciences Leiden; Leiden University Medical Center
- Milena SchönkeLeiden University Medical Center
- Melanie ModderLeiden University Medical Center
- Hannah E. TomLeiden University Medical Center
- Reshma A. LalaiLeiden University Medical Center
- Amanda C. M. PronkLeiden University Medical Center
Abstract
Background
Circadian disturbance (CD) is the consequence of a mismatch between endogenous circadian rhythms, behaviour, and/or environmental cycles, and frequently occurs during shift work. Shift work has been associated with elevated risk for atherosclerotic cardiovascular disease (asCVD) in humans, but evidence for the effectiveness of prevention strategies is lacking.
Methods
Here, we applied time-restricted feeding (TRF) as a strategy to counteract atherosclerosis development during CD in female APOE∗3-Leiden.CETP mice, a well-established model for humanized lipoprotein metabolism. Control groups were subjected to a fixed 12:12 h light-dark cycle, while CD groups were subjected to 6-h phase advancement every 3 days. Groups had either ad libitum (AL) access to food or were subjected to TRF with restricted food access to the dark phase.
Findings
TRF did not prevent the increase in the relative abundance of circulating inflammatory monocytes and elevation of (postprandial) plasma triglycerides during CD. Nonetheless, TRF reduced atherosclerotic lesion size and prevented an elevation in macrophage content of atherosclerotic lesions during CD, while it increased the relative abundance of anti-inflammatory monocytes, prevented activation of T cells, and lowered plasma total cholesterol levels and markers of hepatic cholesterol synthesis. These effects were independent of total food intake.
Interpretation
We propose that time restricted eating could be a promising strategy for the primary prevention of asCVD risk in shift workers, which warrants future study in humans.
Funding
This work was funded by the Novo Nordisk Foundation, the Netherlands Ministry of Social Affairs and Employment, Amsterdam Cardiovascular Sciences, and the Dutch Heart Foundation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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