Effects of Dietary Nitrate Supplementation on Performance during Single and Repeated Bouts of Short-Duration High-Intensity Exercise: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Alsharif NS, Clifford T, Alhebshi A, Rowland SN, Bailey SJ
Antioxidants (Basel, Switzerland) · 20 citations
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Institute for Health and Care Research
- University or hospital
- NIHR Leicester Biomedical Research Centre
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-05-31 · Antioxidants (Basel) · vol. 12 · issue 6 · p. 1194
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 25 citations · more than 90% of similar papers · 2.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 105 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Cardiovascular and exercise physiology · Pharmacological Effects and Assays · Sports Performance and Training
- Keywords
- Meta-analysis, Medicine, Time trial, Placebo, Physical therapy, Repeated measures design, Randomized controlled trial, Dietary Nitrate, Random effects model, Internal medicine, Physical medicine and rehabilitation, Heart rate, Blood pressure, Nitrate, Alternative medicine, Biology
5 authors
From GB, SA
- Nehal S. AlsharifLoughborough University; King Abdulaziz University
- Tom CliffordLoughborough University
- Abrar AlhebshiLoughborough University; Umm al-Qura University
- Samantha N. RowlandLoughborough University
- Stephen J. Bailey · correspondingLoughborough University
Abstract
Inorganic nitrate (NO3-) has emerged as a potential ergogenic aid over the last couple of decades. While recent systematic reviews and meta-analyses have suggested some small positive effects of NO3- supplementation on performance across a range of exercise tasks, the effect of NO3- supplementation on performance during single and repeated bouts of short-duration, high-intensity exercise is unclear. This review was conducted following PRISMA guidelines. MEDLINE and SPORTDiscus were searched from inception to January 2023. A paired analysis model for cross-over trials was incorporated to perform a random effects meta-analysis for each performance outcome and to generate standardized mean differences (SMD) between the NO3- and placebo supplementation conditions. The systematic review and meta-analysis included 27 and 23 studies, respectively. Time to reach peak power (SMD: 0.75, p = 0.02), mean power output (SMD: 0.20, p = 0.02), and total distance covered in the Yo-Yo intermittent recovery level 1 test (SMD: 0.17, p 3- supplementation. Dietary NO3- supplementation had small positive effects on some performance outcomes during single and repeated bouts of high-intensity exercise. Therefore, athletes competing in sports requiring single or repeated bouts of high-intensity exercise may benefit from NO3- supplementation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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