Effects of partial replacement of red and processed meat with non-soya legumes on bone and mineral metabolism and amino acid intakes in BeanMan randomised clinical trial
Itkonen ST, Karhu P, Pellinen T, Lehtovirta M, Kaartinen NE, Männistö S, Päivärinta E, Pajari AM
The British journal of nutrition · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Suomen Kulttuurirahasto
- Nonprofit
- Juho Vainion Säätiö
- Government
- Strategic Research Council
Based on 3 listed funder(s).
Publication
- Published
- 2023-07-10 · Br J Nutr · vol. 131 · issue 1 · pp. 82–91
- Publisher
- Cambridge University Press
- Cited
- 9 citations · more than 87% of similar papers · 2.1× the field average
- References
- 36 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Diet and metabolism studies · Agriculture Sustainability and Environmental Impact
- Keywords
- Legume, Bone remodeling, Chemistry, Food science, Methionine, Medicine, Amino acid, Internal medicine, Biology, Biochemistry, Agronomy
- MeSH
- animals, humans, fabaceae, vegetables, minerals, vitamin d, amino acids, diet, meat, adult, aged, middle aged, male, young adult
8 authors
From FI
- Suvi T. Itkonen · correspondingUniversity of Helsinki
- Piia KarhuUniversity of Helsinki
- Tiina PellinenUniversity of Helsinki
- Mikko LehtovirtaUniversity of Helsinki; Finland University; Institute for Molecular Medicine Finland
- Niina E. KaartinenFinnish Institute for Health and Welfare
- Satu MännistöFinnish Institute for Health and Welfare
Abstract
The transition towards more plant-based diets may pose risks for bone health such as low vitamin D and Ca intakes. Findings for the contribution of animal and plant proteins and their amino acids (AA) to bone health are contradictory. This 6-week clinical trial aimed to investigate whether partial replacement of red and processed meat (RPM) with non-soya legumes affects AA intakes and bone turnover and mineral metabolism in 102 healthy 20-65-year-old men. Participants were randomly assigned to diet groups controlled for RPM and legume intake (designed total protein intake (TPI) 18 E%): the meat group consumed 760 g RPM per week (25 % TPI) and the legume group consumed non-soya legume-based products (20 % TPI) and 200 g RPM per week, the upper limit of the Planetary Health Diet (5 % TPI). No differences in bone (bone-specific alkaline phosphatase; tartrate-resistant acid phosphatase 5b) or mineral metabolism (25-hydroxyvitamin D; parathyroid hormone; fibroblast growth factor 23; phosphate and Ca) markers or Ca and vitamin D intakes were observed between the groups (P > 0·05). Methionine and histidine intakes were higher in the meat group (P ≤ 0·042), whereas the legume group had higher intakes of arginine, asparagine and phenylalanine (P ≤ 0·013). Mean essential AA intakes in both groups met the requirements. Increasing the proportion of non-soya legumes by reducing the amount of RPM in the diet for 6 weeks did not compromise bone turnover and provided on average adequate amounts of AA in healthy men, indicating that this ecologically sustainable dietary change is safe and relatively easy to implement.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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